The Successful Treatment of Metastatic Extraosseous Ewing Sarcoma with Pazopanib

The clinical efficacy and outcomes of pazopanib treatment for metastatic extraosseous Ewing sarcoma remain unclear. We herein report a case of heavily pre-treated metastatic extraosseous Ewing sarcoma in which pazopanib treatment achieved a significant improvement. A 17-year-old girl was referred to...

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Autores principales: Mori, Yoshinori, Kinoshita, Shiori, Kanamori, Takashi, Kataoka, Hiromi, Joh, Takashi, Iida, Shinsuke, Takemoto, Masashi, Kondo, Masahiro, Kuroda, Junko, Komatsu, Hirokazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191593/
https://www.ncbi.nlm.nih.gov/pubmed/29780156
http://dx.doi.org/10.2169/internalmedicine.9879-17
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author Mori, Yoshinori
Kinoshita, Shiori
Kanamori, Takashi
Kataoka, Hiromi
Joh, Takashi
Iida, Shinsuke
Takemoto, Masashi
Kondo, Masahiro
Kuroda, Junko
Komatsu, Hirokazu
author_facet Mori, Yoshinori
Kinoshita, Shiori
Kanamori, Takashi
Kataoka, Hiromi
Joh, Takashi
Iida, Shinsuke
Takemoto, Masashi
Kondo, Masahiro
Kuroda, Junko
Komatsu, Hirokazu
author_sort Mori, Yoshinori
collection PubMed
description The clinical efficacy and outcomes of pazopanib treatment for metastatic extraosseous Ewing sarcoma remain unclear. We herein report a case of heavily pre-treated metastatic extraosseous Ewing sarcoma in which pazopanib treatment achieved a significant improvement. A 17-year-old girl was referred to our hospital due to metastatic extraosseous Ewing sarcoma. The initial cytotoxic chemotherapy was temporarily effective, however, her disease eventually progressed, and she was subsequently treated with pazopanib. The recurrent tumor showed a marked response to pazopanib therapy; the therapeutic effect has lasted for more than 26 months. The present case suggests that pazopanib may be a therapeutic option for extraosseous Ewing sarcoma.
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spelling pubmed-61915932018-10-19 The Successful Treatment of Metastatic Extraosseous Ewing Sarcoma with Pazopanib Mori, Yoshinori Kinoshita, Shiori Kanamori, Takashi Kataoka, Hiromi Joh, Takashi Iida, Shinsuke Takemoto, Masashi Kondo, Masahiro Kuroda, Junko Komatsu, Hirokazu Intern Med Case Report The clinical efficacy and outcomes of pazopanib treatment for metastatic extraosseous Ewing sarcoma remain unclear. We herein report a case of heavily pre-treated metastatic extraosseous Ewing sarcoma in which pazopanib treatment achieved a significant improvement. A 17-year-old girl was referred to our hospital due to metastatic extraosseous Ewing sarcoma. The initial cytotoxic chemotherapy was temporarily effective, however, her disease eventually progressed, and she was subsequently treated with pazopanib. The recurrent tumor showed a marked response to pazopanib therapy; the therapeutic effect has lasted for more than 26 months. The present case suggests that pazopanib may be a therapeutic option for extraosseous Ewing sarcoma. The Japanese Society of Internal Medicine 2018-05-18 2018-09-15 /pmc/articles/PMC6191593/ /pubmed/29780156 http://dx.doi.org/10.2169/internalmedicine.9879-17 Text en Copyright © 2018 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Mori, Yoshinori
Kinoshita, Shiori
Kanamori, Takashi
Kataoka, Hiromi
Joh, Takashi
Iida, Shinsuke
Takemoto, Masashi
Kondo, Masahiro
Kuroda, Junko
Komatsu, Hirokazu
The Successful Treatment of Metastatic Extraosseous Ewing Sarcoma with Pazopanib
title The Successful Treatment of Metastatic Extraosseous Ewing Sarcoma with Pazopanib
title_full The Successful Treatment of Metastatic Extraosseous Ewing Sarcoma with Pazopanib
title_fullStr The Successful Treatment of Metastatic Extraosseous Ewing Sarcoma with Pazopanib
title_full_unstemmed The Successful Treatment of Metastatic Extraosseous Ewing Sarcoma with Pazopanib
title_short The Successful Treatment of Metastatic Extraosseous Ewing Sarcoma with Pazopanib
title_sort successful treatment of metastatic extraosseous ewing sarcoma with pazopanib
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191593/
https://www.ncbi.nlm.nih.gov/pubmed/29780156
http://dx.doi.org/10.2169/internalmedicine.9879-17
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