Fatal Familial Insomnia Initially Developing Parkinsonism Mimicking Dementia with Lewy Bodies

We report a rare case of fatal familial insomnia in a 58-year-old man who initially developed parkinsonism, secondary dementia, and visual hallucinations that were suspected to be due to dementia with Lewy bodies. We evaluated the function of the striatum via dopamine transporter single-photon emiss...

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Detalles Bibliográficos
Autores principales: Fukuoka, Takuya, Nakazato, Yoshihiko, Yamamoto, Masaomi, Miyake, Akifumi, Mitsufuji, Takashi, Yamamoto, Toshimasa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191601/
https://www.ncbi.nlm.nih.gov/pubmed/29709939
http://dx.doi.org/10.2169/internalmedicine.0573-17
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author Fukuoka, Takuya
Nakazato, Yoshihiko
Yamamoto, Masaomi
Miyake, Akifumi
Mitsufuji, Takashi
Yamamoto, Toshimasa
author_facet Fukuoka, Takuya
Nakazato, Yoshihiko
Yamamoto, Masaomi
Miyake, Akifumi
Mitsufuji, Takashi
Yamamoto, Toshimasa
author_sort Fukuoka, Takuya
collection PubMed
description We report a rare case of fatal familial insomnia in a 58-year-old man who initially developed parkinsonism, secondary dementia, and visual hallucinations that were suspected to be due to dementia with Lewy bodies. We evaluated the function of the striatum via dopamine transporter single-photon emission computed tomography (DAT SPECT) using (123)I-ioflupane and found marked presynaptic dopamine dysfunction in the bilateral striatum. This is the first reported case in which the initial symptom of fatal familial insomnia was parkinsonism and in which the dopamine transporter function was evaluated by DAT SPECT.
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spelling pubmed-61916012018-10-19 Fatal Familial Insomnia Initially Developing Parkinsonism Mimicking Dementia with Lewy Bodies Fukuoka, Takuya Nakazato, Yoshihiko Yamamoto, Masaomi Miyake, Akifumi Mitsufuji, Takashi Yamamoto, Toshimasa Intern Med Case Report We report a rare case of fatal familial insomnia in a 58-year-old man who initially developed parkinsonism, secondary dementia, and visual hallucinations that were suspected to be due to dementia with Lewy bodies. We evaluated the function of the striatum via dopamine transporter single-photon emission computed tomography (DAT SPECT) using (123)I-ioflupane and found marked presynaptic dopamine dysfunction in the bilateral striatum. This is the first reported case in which the initial symptom of fatal familial insomnia was parkinsonism and in which the dopamine transporter function was evaluated by DAT SPECT. The Japanese Society of Internal Medicine 2018-04-27 2018-09-15 /pmc/articles/PMC6191601/ /pubmed/29709939 http://dx.doi.org/10.2169/internalmedicine.0573-17 Text en Copyright © 2018 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Fukuoka, Takuya
Nakazato, Yoshihiko
Yamamoto, Masaomi
Miyake, Akifumi
Mitsufuji, Takashi
Yamamoto, Toshimasa
Fatal Familial Insomnia Initially Developing Parkinsonism Mimicking Dementia with Lewy Bodies
title Fatal Familial Insomnia Initially Developing Parkinsonism Mimicking Dementia with Lewy Bodies
title_full Fatal Familial Insomnia Initially Developing Parkinsonism Mimicking Dementia with Lewy Bodies
title_fullStr Fatal Familial Insomnia Initially Developing Parkinsonism Mimicking Dementia with Lewy Bodies
title_full_unstemmed Fatal Familial Insomnia Initially Developing Parkinsonism Mimicking Dementia with Lewy Bodies
title_short Fatal Familial Insomnia Initially Developing Parkinsonism Mimicking Dementia with Lewy Bodies
title_sort fatal familial insomnia initially developing parkinsonism mimicking dementia with lewy bodies
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191601/
https://www.ncbi.nlm.nih.gov/pubmed/29709939
http://dx.doi.org/10.2169/internalmedicine.0573-17
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