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Clinical evaluation of laparoscopic surgery combined with triptorelin acetate in patients with endometriosis and infertility

OBJECTIVE: To investigate the effects of laparoscopic surgery combined with triptorelin acetate, gestrinone and mifepristone on pregnancy rate, pregnancy outcome, long-term recurrence and adverse reactions in patients with endometriosis (EMT) complicated with infertility. METHODS: In this study, 150...

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Detalles Bibliográficos
Autores principales: Xue, Huiling, Liu, Meiyun, Hao, Wanjiao, Li, Ye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Professional Medical Publications 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191787/
https://www.ncbi.nlm.nih.gov/pubmed/30344551
http://dx.doi.org/10.12669/pjms.345.15574
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author Xue, Huiling
Liu, Meiyun
Hao, Wanjiao
Li, Ye
author_facet Xue, Huiling
Liu, Meiyun
Hao, Wanjiao
Li, Ye
author_sort Xue, Huiling
collection PubMed
description OBJECTIVE: To investigate the effects of laparoscopic surgery combined with triptorelin acetate, gestrinone and mifepristone on pregnancy rate, pregnancy outcome, long-term recurrence and adverse reactions in patients with endometriosis (EMT) complicated with infertility. METHODS: In this study, 150 patients with EMT and infertility were selected and randomly divided into triptorelin group (group A), gestrinone group (group B) and mifepristone group (group C), with 50 people in each group. Treatment was with gonadotropin-releasing hormone (GnRH-a) after laparoscopic surgery. RESULTS: The success rate of pregnancy in group A was higher than that in group B and C. The incidence of adverse pregnancy outcome was lower than that in group B and C. Kupperman score and subjective symptom score were lower than those in group B and C before treatment. Sex hormone level and CA125 level were significantly better. In the B and C groups and before treatment; the long-term recurrence rate was significantly lower than the B and C groups; the incidence of adverse reactions was similar. CONCLUSION: Laparoscopic surgery combined with GnRH-a can improve the success and good rate of pregnancy in EMT patients, reduce clinical symptoms, avoid long-term recurrence, and increase the risk of adverse reactions. Triptorelin acetate is superior to gestrinone and mifepristone.
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spelling pubmed-61917872018-10-19 Clinical evaluation of laparoscopic surgery combined with triptorelin acetate in patients with endometriosis and infertility Xue, Huiling Liu, Meiyun Hao, Wanjiao Li, Ye Pak J Med Sci Original Article OBJECTIVE: To investigate the effects of laparoscopic surgery combined with triptorelin acetate, gestrinone and mifepristone on pregnancy rate, pregnancy outcome, long-term recurrence and adverse reactions in patients with endometriosis (EMT) complicated with infertility. METHODS: In this study, 150 patients with EMT and infertility were selected and randomly divided into triptorelin group (group A), gestrinone group (group B) and mifepristone group (group C), with 50 people in each group. Treatment was with gonadotropin-releasing hormone (GnRH-a) after laparoscopic surgery. RESULTS: The success rate of pregnancy in group A was higher than that in group B and C. The incidence of adverse pregnancy outcome was lower than that in group B and C. Kupperman score and subjective symptom score were lower than those in group B and C before treatment. Sex hormone level and CA125 level were significantly better. In the B and C groups and before treatment; the long-term recurrence rate was significantly lower than the B and C groups; the incidence of adverse reactions was similar. CONCLUSION: Laparoscopic surgery combined with GnRH-a can improve the success and good rate of pregnancy in EMT patients, reduce clinical symptoms, avoid long-term recurrence, and increase the risk of adverse reactions. Triptorelin acetate is superior to gestrinone and mifepristone. Professional Medical Publications 2018 /pmc/articles/PMC6191787/ /pubmed/30344551 http://dx.doi.org/10.12669/pjms.345.15574 Text en Copyright: © Pakistan Journal of Medical Sciences http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Xue, Huiling
Liu, Meiyun
Hao, Wanjiao
Li, Ye
Clinical evaluation of laparoscopic surgery combined with triptorelin acetate in patients with endometriosis and infertility
title Clinical evaluation of laparoscopic surgery combined with triptorelin acetate in patients with endometriosis and infertility
title_full Clinical evaluation of laparoscopic surgery combined with triptorelin acetate in patients with endometriosis and infertility
title_fullStr Clinical evaluation of laparoscopic surgery combined with triptorelin acetate in patients with endometriosis and infertility
title_full_unstemmed Clinical evaluation of laparoscopic surgery combined with triptorelin acetate in patients with endometriosis and infertility
title_short Clinical evaluation of laparoscopic surgery combined with triptorelin acetate in patients with endometriosis and infertility
title_sort clinical evaluation of laparoscopic surgery combined with triptorelin acetate in patients with endometriosis and infertility
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191787/
https://www.ncbi.nlm.nih.gov/pubmed/30344551
http://dx.doi.org/10.12669/pjms.345.15574
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