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Temozolomide-Perillyl alcohol conjugate impairs Mitophagy flux by inducing lysosomal dysfunction in non-small cell lung Cancer cells and sensitizes them to irradiation

BACKGROUND: Temozolomide-perillyl alcohol conjugate (TMZ-POH), a novel Temozolomide (TMZ) analog developed based on the conjugation of TMZ and perillyl alcohol (POH), displayed strong anticancer potency in multiple cancer types. In this study, we aimed to clarify the relationship between TMZ-POH and...

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Detalles Bibliográficos
Autores principales:	Chang, Minghui, Song, Xingguo, Geng, Xinran, Wang, Xingwu, Wang, Weijun, Chen, Thomas C., Xie, Li, Song, Xianrang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191917/ https://www.ncbi.nlm.nih.gov/pubmed/30326943 http://dx.doi.org/10.1186/s13046-018-0905-1

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