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Non-apoptotic Caspase regulation of stem cell properties

The evolutionarily conserved family of proteins called caspases are the main factors mediating the orchestrated programme of cell suicide known as apoptosis. Since this protein family was associated with this essential biological function, the majority of scientific efforts were focused towards unde...

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Detalles Bibliográficos
Autores principales: Baena-Lopez, Luis Alberto, Arthurton, Lewis, Xu, Derek Cui, Galasso, Alessia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191935/
https://www.ncbi.nlm.nih.gov/pubmed/29102718
http://dx.doi.org/10.1016/j.semcdb.2017.10.034
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author Baena-Lopez, Luis Alberto
Arthurton, Lewis
Xu, Derek Cui
Galasso, Alessia
author_facet Baena-Lopez, Luis Alberto
Arthurton, Lewis
Xu, Derek Cui
Galasso, Alessia
author_sort Baena-Lopez, Luis Alberto
collection PubMed
description The evolutionarily conserved family of proteins called caspases are the main factors mediating the orchestrated programme of cell suicide known as apoptosis. Since this protein family was associated with this essential biological function, the majority of scientific efforts were focused towards understanding their molecular activation and function during cell death. However, an emerging body of evidence has highlighted a repertoire of non-lethal roles within a large variety of cell types, including stem cells. Here we intend to provide a comprehensive overview of the key role of caspases as regulators of stem cell properties. Finally, we briefly discuss the possible pathological consequences of caspase malfunction in stem cells, and the therapeutic potential of caspase regulation applied to this context.
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spelling pubmed-61919352018-10-19 Non-apoptotic Caspase regulation of stem cell properties Baena-Lopez, Luis Alberto Arthurton, Lewis Xu, Derek Cui Galasso, Alessia Semin Cell Dev Biol Article The evolutionarily conserved family of proteins called caspases are the main factors mediating the orchestrated programme of cell suicide known as apoptosis. Since this protein family was associated with this essential biological function, the majority of scientific efforts were focused towards understanding their molecular activation and function during cell death. However, an emerging body of evidence has highlighted a repertoire of non-lethal roles within a large variety of cell types, including stem cells. Here we intend to provide a comprehensive overview of the key role of caspases as regulators of stem cell properties. Finally, we briefly discuss the possible pathological consequences of caspase malfunction in stem cells, and the therapeutic potential of caspase regulation applied to this context. Academic Press 2018-10 /pmc/articles/PMC6191935/ /pubmed/29102718 http://dx.doi.org/10.1016/j.semcdb.2017.10.034 Text en © 2017 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Baena-Lopez, Luis Alberto
Arthurton, Lewis
Xu, Derek Cui
Galasso, Alessia
Non-apoptotic Caspase regulation of stem cell properties
title Non-apoptotic Caspase regulation of stem cell properties
title_full Non-apoptotic Caspase regulation of stem cell properties
title_fullStr Non-apoptotic Caspase regulation of stem cell properties
title_full_unstemmed Non-apoptotic Caspase regulation of stem cell properties
title_short Non-apoptotic Caspase regulation of stem cell properties
title_sort non-apoptotic caspase regulation of stem cell properties
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191935/
https://www.ncbi.nlm.nih.gov/pubmed/29102718
http://dx.doi.org/10.1016/j.semcdb.2017.10.034
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