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Uridylation by TUT4/7 Restricts Retrotransposition of Human LINE-1s

LINE-1 retrotransposition is tightly restricted by layers of regulatory control, with epigenetic pathways being the best characterized. Looking at post-transcriptional regulation, we now show that LINE-1 mRNA 3′ ends are pervasively uridylated in various human cellular models and in mouse testes. TU...

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Detalles Bibliográficos
Autores principales:	Warkocki, Zbigniew, Krawczyk, Paweł S., Adamska, Dorota, Bijata, Krystian, Garcia-Perez, Jose L., Dziembowski, Andrzej
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191937/ https://www.ncbi.nlm.nih.gov/pubmed/30122351 http://dx.doi.org/10.1016/j.cell.2018.07.022

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