Solution pH jump during antibody and Fc-fusion protein thaw leads to increased aggregation

Freeze-thaw cycles impact the amount of aggregation observed in antibodies and Fc-fusion proteins. Various formulation strategies are used to mitigate the amount of aggregation that occurs upon putting a protein solution through a freeze-thaw cycle. Additionally, low pH solutions cause native antibo...

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Detalles Bibliográficos
Autores principales: Kent, Kevin P., Schroeder, Chad E., Sharma, Chandana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Xi'an Jiaotong University 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191964/
https://www.ncbi.nlm.nih.gov/pubmed/30345143
http://dx.doi.org/10.1016/j.jpha.2017.09.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191964/
https://www.ncbi.nlm.nih.gov/pubmed/30345143
http://dx.doi.org/10.1016/j.jpha.2017.09.002

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