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Alpha-synuclein overexpression in the olfactory bulb initiates prodromal symptoms and pathology of Parkinson’s disease

BACKGROUND: Parkinson’s disease (PD) is a neurodegenerative disease characterized by intraneuronal Lewy Body (LB) aggregates composed of misfolded alpha-synuclein (α-syn). The spread of misfolded α-syn follows a typical pattern: starting in the olfactory bulb (OB) and the gut, this pathology is foll...

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Detalles Bibliográficos
Autores principales:	Niu, Haichen, Shen, Lingyu, Li, Tongzhou, Ren, Chao, Ding, Sheng, Wang, Lei, Zhang, Zhonghai, Liu, Xiaoyu, Zhang, Qiang, Geng, Deqin, Wu, Xiujuan, Li, Haiying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192070/ https://www.ncbi.nlm.nih.gov/pubmed/30356861 http://dx.doi.org/10.1186/s40035-018-0128-6

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