Exploring Seipin: From Biochemistry to Bioinformatics Predictions

Seipin is a nonenzymatic protein encoded by the BSCL2 gene. It is involved in lipodystrophy and seipinopathy diseases. Named in 2001, all seipin functions are still far from being understood. Therefore, we reviewed much of the research, trying to find a pattern that could explain commonly observed f...

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Detalles Bibliográficos
Autores principales: Craveiro Sarmento, Aquiles Sales, de Azevedo Medeiros, Lázaro Batista, Agnez-Lima, Lucymara Fassarella, Lima, Josivan Gomes, de Melo Campos, Julliane Tamara Araújo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192094/
https://www.ncbi.nlm.nih.gov/pubmed/30402103
http://dx.doi.org/10.1155/2018/5207608
Descripción
Sumario:Seipin is a nonenzymatic protein encoded by the BSCL2 gene. It is involved in lipodystrophy and seipinopathy diseases. Named in 2001, all seipin functions are still far from being understood. Therefore, we reviewed much of the research, trying to find a pattern that could explain commonly observed features of seipin expression disorders. Likewise, this review shows how this protein seems to have tissue-specific functions. In an integrative view, we conclude by proposing a theoretical model to explain how seipin might be involved in the triacylglycerol synthesis pathway.

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