Malignant Transformation of Testicular Teratoma to PNET, Adenocarcinoma, and Osteosarcoma with Complete Remission after Surgery and Combination Chemotherapy in a Young Adult Male

Mixed germ cell tumors (GCT) with teratoma components can transform into somatic malignancies which can include histologies outside of traditional germ cell lineages. We describe a case of an 18-year-old man with a metastatic testicular GCT with both mature and immature teratoma components containin...

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Autores principales: Shaw, Angela, Morrell, Miriam, Weissferdt, Annikka, Hayes-Jordan, Andrea, Harrison, Douglas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192168/
https://www.ncbi.nlm.nih.gov/pubmed/30402315
http://dx.doi.org/10.1155/2018/8460603
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author Shaw, Angela
Morrell, Miriam
Weissferdt, Annikka
Hayes-Jordan, Andrea
Harrison, Douglas
author_facet Shaw, Angela
Morrell, Miriam
Weissferdt, Annikka
Hayes-Jordan, Andrea
Harrison, Douglas
author_sort Shaw, Angela
collection PubMed
description Mixed germ cell tumors (GCT) with teratoma components can transform into somatic malignancies which can include histologies outside of traditional germ cell lineages. We describe a case of an 18-year-old man with a metastatic testicular GCT with both mature and immature teratoma components containing malignant transformation into multiple histologies including PNET in the primary testicular tumor and osteosarcoma in a separate pulmonary metastatic lesion. Management with targeted chemotherapy resulted in a durable remission. This is the first reported case that we know of a patient with primary PNET malignant transformation with subsequent metastatic transformation to osteosarcoma.
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spelling pubmed-61921682018-11-06 Malignant Transformation of Testicular Teratoma to PNET, Adenocarcinoma, and Osteosarcoma with Complete Remission after Surgery and Combination Chemotherapy in a Young Adult Male Shaw, Angela Morrell, Miriam Weissferdt, Annikka Hayes-Jordan, Andrea Harrison, Douglas Case Rep Oncol Med Case Report Mixed germ cell tumors (GCT) with teratoma components can transform into somatic malignancies which can include histologies outside of traditional germ cell lineages. We describe a case of an 18-year-old man with a metastatic testicular GCT with both mature and immature teratoma components containing malignant transformation into multiple histologies including PNET in the primary testicular tumor and osteosarcoma in a separate pulmonary metastatic lesion. Management with targeted chemotherapy resulted in a durable remission. This is the first reported case that we know of a patient with primary PNET malignant transformation with subsequent metastatic transformation to osteosarcoma. Hindawi 2018-10-03 /pmc/articles/PMC6192168/ /pubmed/30402315 http://dx.doi.org/10.1155/2018/8460603 Text en Copyright © 2018 Angela Shaw et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Shaw, Angela
Morrell, Miriam
Weissferdt, Annikka
Hayes-Jordan, Andrea
Harrison, Douglas
Malignant Transformation of Testicular Teratoma to PNET, Adenocarcinoma, and Osteosarcoma with Complete Remission after Surgery and Combination Chemotherapy in a Young Adult Male
title Malignant Transformation of Testicular Teratoma to PNET, Adenocarcinoma, and Osteosarcoma with Complete Remission after Surgery and Combination Chemotherapy in a Young Adult Male
title_full Malignant Transformation of Testicular Teratoma to PNET, Adenocarcinoma, and Osteosarcoma with Complete Remission after Surgery and Combination Chemotherapy in a Young Adult Male
title_fullStr Malignant Transformation of Testicular Teratoma to PNET, Adenocarcinoma, and Osteosarcoma with Complete Remission after Surgery and Combination Chemotherapy in a Young Adult Male
title_full_unstemmed Malignant Transformation of Testicular Teratoma to PNET, Adenocarcinoma, and Osteosarcoma with Complete Remission after Surgery and Combination Chemotherapy in a Young Adult Male
title_short Malignant Transformation of Testicular Teratoma to PNET, Adenocarcinoma, and Osteosarcoma with Complete Remission after Surgery and Combination Chemotherapy in a Young Adult Male
title_sort malignant transformation of testicular teratoma to pnet, adenocarcinoma, and osteosarcoma with complete remission after surgery and combination chemotherapy in a young adult male
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192168/
https://www.ncbi.nlm.nih.gov/pubmed/30402315
http://dx.doi.org/10.1155/2018/8460603
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