Novel molecular insights and new therapeutic strategies in osteosarcoma

Osteosarcoma (OS) is one of the most prevalent malignant cancers with lower survival and poor overall prognosis mainly in children and adolescents. Identifying the molecular mechanisms and OS stem cells (OSCs) as new concepts involved in disease pathogenesis and progression may potentially lead to n...

Descripción completa

Detalles Bibliográficos
Autores principales: Otoukesh, Babak, Boddouhi, Bahram, Moghtadaei, Mehdi, Kaghazian, Peyman, Kaghazian, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192346/
https://www.ncbi.nlm.nih.gov/pubmed/30349420
http://dx.doi.org/10.1186/s12935-018-0654-4
_version_ 1783363892800389120
author Otoukesh, Babak
Boddouhi, Bahram
Moghtadaei, Mehdi
Kaghazian, Peyman
Kaghazian, Maria
author_facet Otoukesh, Babak
Boddouhi, Bahram
Moghtadaei, Mehdi
Kaghazian, Peyman
Kaghazian, Maria
author_sort Otoukesh, Babak
collection PubMed
description Osteosarcoma (OS) is one of the most prevalent malignant cancers with lower survival and poor overall prognosis mainly in children and adolescents. Identifying the molecular mechanisms and OS stem cells (OSCs) as new concepts involved in disease pathogenesis and progression may potentially lead to new therapeutic targets. Therefore, therapeutic targeting of OSCs can be one of the most important and effective strategies for the treatment of OS. This review describes the new molecular targets of OS as well as novel therapeutic approaches in the design of future investigations and treatment.
format Online
Article
Text
id pubmed-6192346
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-61923462018-10-22 Novel molecular insights and new therapeutic strategies in osteosarcoma Otoukesh, Babak Boddouhi, Bahram Moghtadaei, Mehdi Kaghazian, Peyman Kaghazian, Maria Cancer Cell Int Review Osteosarcoma (OS) is one of the most prevalent malignant cancers with lower survival and poor overall prognosis mainly in children and adolescents. Identifying the molecular mechanisms and OS stem cells (OSCs) as new concepts involved in disease pathogenesis and progression may potentially lead to new therapeutic targets. Therefore, therapeutic targeting of OSCs can be one of the most important and effective strategies for the treatment of OS. This review describes the new molecular targets of OS as well as novel therapeutic approaches in the design of future investigations and treatment. BioMed Central 2018-10-16 /pmc/articles/PMC6192346/ /pubmed/30349420 http://dx.doi.org/10.1186/s12935-018-0654-4 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Otoukesh, Babak
Boddouhi, Bahram
Moghtadaei, Mehdi
Kaghazian, Peyman
Kaghazian, Maria
Novel molecular insights and new therapeutic strategies in osteosarcoma
title Novel molecular insights and new therapeutic strategies in osteosarcoma
title_full Novel molecular insights and new therapeutic strategies in osteosarcoma
title_fullStr Novel molecular insights and new therapeutic strategies in osteosarcoma
title_full_unstemmed Novel molecular insights and new therapeutic strategies in osteosarcoma
title_short Novel molecular insights and new therapeutic strategies in osteosarcoma
title_sort novel molecular insights and new therapeutic strategies in osteosarcoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192346/
https://www.ncbi.nlm.nih.gov/pubmed/30349420
http://dx.doi.org/10.1186/s12935-018-0654-4
work_keys_str_mv AT otoukeshbabak novelmolecularinsightsandnewtherapeuticstrategiesinosteosarcoma
AT boddouhibahram novelmolecularinsightsandnewtherapeuticstrategiesinosteosarcoma
AT moghtadaeimehdi novelmolecularinsightsandnewtherapeuticstrategiesinosteosarcoma
AT kaghazianpeyman novelmolecularinsightsandnewtherapeuticstrategiesinosteosarcoma
AT kaghazianmaria novelmolecularinsightsandnewtherapeuticstrategiesinosteosarcoma

Ejemplares similares