Cargando…

Improvement of Glucose Metabolism Following Long-Term Taurocholic Acid Gavage in a Diabetic Rat Model

BACKGROUND: Bile acids (BAs) are signaling molecules that participate in maintaining glucose homeostasis. Acute enteral infusion of BAs potently reduces the glycemic response to glucose, associated with an increase of incretin hormones. However, the effect of long-term supplementation of BAs on gluc...

Descripción completa

Detalles Bibliográficos
Autores principales: Cheng, Zhiqiang, Liu, Guozhi, Zhang, Xiang, Bi, Dongsong, Hu, Sanyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192455/
https://www.ncbi.nlm.nih.gov/pubmed/30298865
http://dx.doi.org/10.12659/MSM.912429
_version_ 1783363912846016512
author Cheng, Zhiqiang
Liu, Guozhi
Zhang, Xiang
Bi, Dongsong
Hu, Sanyuan
author_facet Cheng, Zhiqiang
Liu, Guozhi
Zhang, Xiang
Bi, Dongsong
Hu, Sanyuan
author_sort Cheng, Zhiqiang
collection PubMed
description BACKGROUND: Bile acids (BAs) are signaling molecules that participate in maintaining glucose homeostasis. Acute enteral infusion of BAs potently reduces the glycemic response to glucose, associated with an increase of incretin hormones. However, the effect of long-term supplementation of BAs on glucose metabolism has not been fully investigated. MATERIAL/METHODS: Thirty diabetic rats were assigned to a control group (n=10), a low TCA group (L-TCA group, n=10), and a high TCA group (H-TCA group, n=10). Rats in the control group were fed a regular high-fat diet (HFD), while rats in the L-TCA group and H-TCA group were fed a TCA (taurocholic acid)-mixed HFD with the concentrations of 0.05% and 0.3%, respectively, to control the intake of HFD and TCA. Energy intake, body weight, serum insulin, glucose tolerance, insulin sensitivity, GLP-1, and total serum BAs were measured at week 2 and week 12. RESULTS: At week 2 there were no significant differences in body weight, daily energy intake, glucose tolerance, serum insulin, insulin sensitivity, GLP-1, or fasting total serum BAs between the 3 groups. At week 12, fasting blood glucose and intragastric glucose tolerance were better in the H-TCA group, with significantly greater insulin and GLP-1 secretion and better insulin sensitivity; no significant differences in body weight, energy intake, or total fasting serum BAs were observed. CONCLUSIONS: Long-term supplementation with small doses of TCA was demonstrated to improve glucose metabolism in a diabetic rat model and may be a potential target for diabetes control.
format Online
Article
Text
id pubmed-6192455
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher International Scientific Literature, Inc.
record_format MEDLINE/PubMed
spelling pubmed-61924552018-10-19 Improvement of Glucose Metabolism Following Long-Term Taurocholic Acid Gavage in a Diabetic Rat Model Cheng, Zhiqiang Liu, Guozhi Zhang, Xiang Bi, Dongsong Hu, Sanyuan Med Sci Monit Animal Study BACKGROUND: Bile acids (BAs) are signaling molecules that participate in maintaining glucose homeostasis. Acute enteral infusion of BAs potently reduces the glycemic response to glucose, associated with an increase of incretin hormones. However, the effect of long-term supplementation of BAs on glucose metabolism has not been fully investigated. MATERIAL/METHODS: Thirty diabetic rats were assigned to a control group (n=10), a low TCA group (L-TCA group, n=10), and a high TCA group (H-TCA group, n=10). Rats in the control group were fed a regular high-fat diet (HFD), while rats in the L-TCA group and H-TCA group were fed a TCA (taurocholic acid)-mixed HFD with the concentrations of 0.05% and 0.3%, respectively, to control the intake of HFD and TCA. Energy intake, body weight, serum insulin, glucose tolerance, insulin sensitivity, GLP-1, and total serum BAs were measured at week 2 and week 12. RESULTS: At week 2 there were no significant differences in body weight, daily energy intake, glucose tolerance, serum insulin, insulin sensitivity, GLP-1, or fasting total serum BAs between the 3 groups. At week 12, fasting blood glucose and intragastric glucose tolerance were better in the H-TCA group, with significantly greater insulin and GLP-1 secretion and better insulin sensitivity; no significant differences in body weight, energy intake, or total fasting serum BAs were observed. CONCLUSIONS: Long-term supplementation with small doses of TCA was demonstrated to improve glucose metabolism in a diabetic rat model and may be a potential target for diabetes control. International Scientific Literature, Inc. 2018-10-09 /pmc/articles/PMC6192455/ /pubmed/30298865 http://dx.doi.org/10.12659/MSM.912429 Text en © Med Sci Monit, 2018 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) )
spellingShingle Animal Study
Cheng, Zhiqiang
Liu, Guozhi
Zhang, Xiang
Bi, Dongsong
Hu, Sanyuan
Improvement of Glucose Metabolism Following Long-Term Taurocholic Acid Gavage in a Diabetic Rat Model
title Improvement of Glucose Metabolism Following Long-Term Taurocholic Acid Gavage in a Diabetic Rat Model
title_full Improvement of Glucose Metabolism Following Long-Term Taurocholic Acid Gavage in a Diabetic Rat Model
title_fullStr Improvement of Glucose Metabolism Following Long-Term Taurocholic Acid Gavage in a Diabetic Rat Model
title_full_unstemmed Improvement of Glucose Metabolism Following Long-Term Taurocholic Acid Gavage in a Diabetic Rat Model
title_short Improvement of Glucose Metabolism Following Long-Term Taurocholic Acid Gavage in a Diabetic Rat Model
title_sort improvement of glucose metabolism following long-term taurocholic acid gavage in a diabetic rat model
topic Animal Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192455/
https://www.ncbi.nlm.nih.gov/pubmed/30298865
http://dx.doi.org/10.12659/MSM.912429
work_keys_str_mv AT chengzhiqiang improvementofglucosemetabolismfollowinglongtermtaurocholicacidgavageinadiabeticratmodel
AT liuguozhi improvementofglucosemetabolismfollowinglongtermtaurocholicacidgavageinadiabeticratmodel
AT zhangxiang improvementofglucosemetabolismfollowinglongtermtaurocholicacidgavageinadiabeticratmodel
AT bidongsong improvementofglucosemetabolismfollowinglongtermtaurocholicacidgavageinadiabeticratmodel
AT husanyuan improvementofglucosemetabolismfollowinglongtermtaurocholicacidgavageinadiabeticratmodel