Functional abnormalities in induced Pluripotent Stem Cell-derived cardiomyocytes generated from titin-mutated patients with dilated cardiomyopathy

AIMS: Dilated cardiomyopathy (DCM), a myocardial disorder that can result in progressive heart failure and arrhythmias, is defined by ventricular chamber enlargement and dilatation, and systolic dysfunction. Despite extensive research, the pathological mechanisms of DCM are unclear mainly due to num...

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Detalles Bibliográficos
Autores principales: Schick, Revital, Mekies, Lucy N., Shemer, Yuval, Eisen, Binyamin, Hallas, Tova, Ben Jehuda, Ronen, Ben-Ari, Meital, Szantai, Agnes, Willi, Lubna, Shulman, Rita, Gramlich, Michael, Pane, Luna Simona, My, Ilaria, Freimark, Dov, Murgia, Marta, Santamaria, Gianluca, Gherghiceanu, Mihaela, Arad, Michael, Moretti, Alessandra, Binah, Ofer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192629/
https://www.ncbi.nlm.nih.gov/pubmed/30332462
http://dx.doi.org/10.1371/journal.pone.0205719

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