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A novel pH-dependent membrane peptide that binds to EphA2 and inhibits cell migration

Misregulation of the signaling axis formed by the receptor tyrosine kinase (RTK) EphA2 and its ligand, ephrinA1, causes aberrant cell-cell contacts that contribute to metastasis. Solid tumors are characterized by an acidic extracellular medium. We intend to take advantage of this tumor feature to de...

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Detalles Bibliográficos
Autores principales:	Alves, Daiane S, Westerfield, Justin M, Shi, Xiaojun, Nguyen, Vanessa P, Stefanski, Katherine M, Booth, Kristen R, Kim, Soyeon, Morrell-Falvey, Jennifer, Wang, Bing-Cheng, Abel, Steven M, Smith, Adam W, Barrera, Francisco N
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2018
Materias:	Structural Biology and Molecular Biophysics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192698/ https://www.ncbi.nlm.nih.gov/pubmed/30222105 http://dx.doi.org/10.7554/eLife.36645

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