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Current EU research activities on combined exposure to multiple chemicals()

Humans and wildlife are exposed to an intractably large number of different combinations of chemicals via food, water, air, consumer products, and other media and sources. This raises concerns about their impact on public and environmental health. The risk assessment of chemicals for regulatory purp...

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Autores principales: Bopp, Stephanie K., Barouki, Robert, Brack, Werner, Dalla Costa, Silvia, Dorne, Jean-Lou C.M., Drakvik, Paula E., Faust, Michael, Karjalainen, Tuomo K., Kephalopoulos, Stylianos, van Klaveren, Jacob, Kolossa-Gehring, Marike, Kortenkamp, Andreas, Lebret, Erik, Lettieri, Teresa, Nørager, Sofie, Rüegg, Joëlle, Tarazona, Jose V., Trier, Xenia, van de Water, Bob, van Gils, Jos, Bergman, Åke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192826/
https://www.ncbi.nlm.nih.gov/pubmed/30170309
http://dx.doi.org/10.1016/j.envint.2018.07.037
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author Bopp, Stephanie K.
Barouki, Robert
Brack, Werner
Dalla Costa, Silvia
Dorne, Jean-Lou C.M.
Drakvik, Paula E.
Faust, Michael
Karjalainen, Tuomo K.
Kephalopoulos, Stylianos
van Klaveren, Jacob
Kolossa-Gehring, Marike
Kortenkamp, Andreas
Lebret, Erik
Lettieri, Teresa
Nørager, Sofie
Rüegg, Joëlle
Tarazona, Jose V.
Trier, Xenia
van de Water, Bob
van Gils, Jos
Bergman, Åke
author_facet Bopp, Stephanie K.
Barouki, Robert
Brack, Werner
Dalla Costa, Silvia
Dorne, Jean-Lou C.M.
Drakvik, Paula E.
Faust, Michael
Karjalainen, Tuomo K.
Kephalopoulos, Stylianos
van Klaveren, Jacob
Kolossa-Gehring, Marike
Kortenkamp, Andreas
Lebret, Erik
Lettieri, Teresa
Nørager, Sofie
Rüegg, Joëlle
Tarazona, Jose V.
Trier, Xenia
van de Water, Bob
van Gils, Jos
Bergman, Åke
author_sort Bopp, Stephanie K.
collection PubMed
description Humans and wildlife are exposed to an intractably large number of different combinations of chemicals via food, water, air, consumer products, and other media and sources. This raises concerns about their impact on public and environmental health. The risk assessment of chemicals for regulatory purposes mainly relies on the assessment of individual chemicals. If exposure to multiple chemicals is considered in a legislative framework, it is usually limited to chemicals falling within this framework and co-exposure to chemicals that are covered by a different regulatory framework is often neglected. Methodologies and guidance for assessing risks from combined exposure to multiple chemicals have been developed for different regulatory sectors, however, a harmonised, consistent approach for performing mixture risk assessments and management across different regulatory sectors is lacking. At the time of this publication, several EU research projects are running, funded by the current European Research and Innovation Programme Horizon 2020 or the Seventh Framework Programme. They aim at addressing knowledge gaps and developing methodologies to better assess chemical mixtures, by generating and making available internal and external exposure data, developing models for exposure assessment, developing tools for in silico and in vitro effect assessment to be applied in a tiered framework and for grouping of chemicals, as well as developing joint epidemiological-toxicological approaches for mixture risk assessment and for prioritising mixtures of concern. The projects EDC-MixRisk, EuroMix, EUToxRisk, HBM4EU and SOLUTIONS have started an exchange between the consortia, European Commission Services and EU Agencies, in order to identify where new methodologies have become available and where remaining gaps need to be further addressed. This paper maps how the different projects contribute to the data needs and assessment methodologies and identifies remaining challenges to be further addressed for the assessment of chemical mixtures.
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spelling pubmed-61928262018-11-01 Current EU research activities on combined exposure to multiple chemicals() Bopp, Stephanie K. Barouki, Robert Brack, Werner Dalla Costa, Silvia Dorne, Jean-Lou C.M. Drakvik, Paula E. Faust, Michael Karjalainen, Tuomo K. Kephalopoulos, Stylianos van Klaveren, Jacob Kolossa-Gehring, Marike Kortenkamp, Andreas Lebret, Erik Lettieri, Teresa Nørager, Sofie Rüegg, Joëlle Tarazona, Jose V. Trier, Xenia van de Water, Bob van Gils, Jos Bergman, Åke Environ Int Article Humans and wildlife are exposed to an intractably large number of different combinations of chemicals via food, water, air, consumer products, and other media and sources. This raises concerns about their impact on public and environmental health. The risk assessment of chemicals for regulatory purposes mainly relies on the assessment of individual chemicals. If exposure to multiple chemicals is considered in a legislative framework, it is usually limited to chemicals falling within this framework and co-exposure to chemicals that are covered by a different regulatory framework is often neglected. Methodologies and guidance for assessing risks from combined exposure to multiple chemicals have been developed for different regulatory sectors, however, a harmonised, consistent approach for performing mixture risk assessments and management across different regulatory sectors is lacking. At the time of this publication, several EU research projects are running, funded by the current European Research and Innovation Programme Horizon 2020 or the Seventh Framework Programme. They aim at addressing knowledge gaps and developing methodologies to better assess chemical mixtures, by generating and making available internal and external exposure data, developing models for exposure assessment, developing tools for in silico and in vitro effect assessment to be applied in a tiered framework and for grouping of chemicals, as well as developing joint epidemiological-toxicological approaches for mixture risk assessment and for prioritising mixtures of concern. The projects EDC-MixRisk, EuroMix, EUToxRisk, HBM4EU and SOLUTIONS have started an exchange between the consortia, European Commission Services and EU Agencies, in order to identify where new methodologies have become available and where remaining gaps need to be further addressed. This paper maps how the different projects contribute to the data needs and assessment methodologies and identifies remaining challenges to be further addressed for the assessment of chemical mixtures. Elsevier Science 2018-11 /pmc/articles/PMC6192826/ /pubmed/30170309 http://dx.doi.org/10.1016/j.envint.2018.07.037 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Bopp, Stephanie K.
Barouki, Robert
Brack, Werner
Dalla Costa, Silvia
Dorne, Jean-Lou C.M.
Drakvik, Paula E.
Faust, Michael
Karjalainen, Tuomo K.
Kephalopoulos, Stylianos
van Klaveren, Jacob
Kolossa-Gehring, Marike
Kortenkamp, Andreas
Lebret, Erik
Lettieri, Teresa
Nørager, Sofie
Rüegg, Joëlle
Tarazona, Jose V.
Trier, Xenia
van de Water, Bob
van Gils, Jos
Bergman, Åke
Current EU research activities on combined exposure to multiple chemicals()
title Current EU research activities on combined exposure to multiple chemicals()
title_full Current EU research activities on combined exposure to multiple chemicals()
title_fullStr Current EU research activities on combined exposure to multiple chemicals()
title_full_unstemmed Current EU research activities on combined exposure to multiple chemicals()
title_short Current EU research activities on combined exposure to multiple chemicals()
title_sort current eu research activities on combined exposure to multiple chemicals()
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192826/
https://www.ncbi.nlm.nih.gov/pubmed/30170309
http://dx.doi.org/10.1016/j.envint.2018.07.037
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