Delayed Terminal Ileal Perforation in a Relapsed/Refractory B-Cell Lymphoma Patient with Rapid Remission Following Chimeric Antigen Receptor T-Cell Therapy

Chimeric antigen receptor T-cell strategy targeting CD19 (CART19) has prominent anti-tumor effect for relapsed/refractory B-cell lymphomas. CART19-associated complications have been gradually recognized, however, late-onset complications have not been extensively studied. Herein, for the first time...

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Autores principales: Hu, Yongxian, Wang, Jiasheng, Pu, Chengfei, Zhao, Kui, Cui, Qu, Wei, Guoqing, Wu, Wenjun, Xiao, Lei, Xiao, Yang, Wang, Jinping, Wu, Zhao, Huang, He
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Cancer Association 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192928/
https://www.ncbi.nlm.nih.gov/pubmed/29397660
http://dx.doi.org/10.4143/crt.2017.473
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author Hu, Yongxian
Wang, Jiasheng
Pu, Chengfei
Zhao, Kui
Cui, Qu
Wei, Guoqing
Wu, Wenjun
Xiao, Lei
Xiao, Yang
Wang, Jinping
Wu, Zhao
Huang, He
author_facet Hu, Yongxian
Wang, Jiasheng
Pu, Chengfei
Zhao, Kui
Cui, Qu
Wei, Guoqing
Wu, Wenjun
Xiao, Lei
Xiao, Yang
Wang, Jinping
Wu, Zhao
Huang, He
author_sort Hu, Yongxian
collection PubMed
description Chimeric antigen receptor T-cell strategy targeting CD19 (CART19) has prominent anti-tumor effect for relapsed/refractory B-cell lymphomas. CART19-associated complications have been gradually recognized, however, late-onset complications have not been extensively studied. Herein, for the first time we report a diffuse large B-cell lymphoma patient with terminal ileum involvement obtained rapid remission and developed spontaneous terminal ileal perforation 38 days following CART19 infusion. The late-onset perforation reminds us that, for the safety of CART treatment, more cautions are warranted for the management of delayed GI complications.
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spelling pubmed-61929282018-10-24 Delayed Terminal Ileal Perforation in a Relapsed/Refractory B-Cell Lymphoma Patient with Rapid Remission Following Chimeric Antigen Receptor T-Cell Therapy Hu, Yongxian Wang, Jiasheng Pu, Chengfei Zhao, Kui Cui, Qu Wei, Guoqing Wu, Wenjun Xiao, Lei Xiao, Yang Wang, Jinping Wu, Zhao Huang, He Cancer Res Treat Case Report Chimeric antigen receptor T-cell strategy targeting CD19 (CART19) has prominent anti-tumor effect for relapsed/refractory B-cell lymphomas. CART19-associated complications have been gradually recognized, however, late-onset complications have not been extensively studied. Herein, for the first time we report a diffuse large B-cell lymphoma patient with terminal ileum involvement obtained rapid remission and developed spontaneous terminal ileal perforation 38 days following CART19 infusion. The late-onset perforation reminds us that, for the safety of CART treatment, more cautions are warranted for the management of delayed GI complications. Korean Cancer Association 2018-10 2018-02-05 /pmc/articles/PMC6192928/ /pubmed/29397660 http://dx.doi.org/10.4143/crt.2017.473 Text en Copyright © 2018 by the Korean Cancer Association This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Hu, Yongxian
Wang, Jiasheng
Pu, Chengfei
Zhao, Kui
Cui, Qu
Wei, Guoqing
Wu, Wenjun
Xiao, Lei
Xiao, Yang
Wang, Jinping
Wu, Zhao
Huang, He
Delayed Terminal Ileal Perforation in a Relapsed/Refractory B-Cell Lymphoma Patient with Rapid Remission Following Chimeric Antigen Receptor T-Cell Therapy
title Delayed Terminal Ileal Perforation in a Relapsed/Refractory B-Cell Lymphoma Patient with Rapid Remission Following Chimeric Antigen Receptor T-Cell Therapy
title_full Delayed Terminal Ileal Perforation in a Relapsed/Refractory B-Cell Lymphoma Patient with Rapid Remission Following Chimeric Antigen Receptor T-Cell Therapy
title_fullStr Delayed Terminal Ileal Perforation in a Relapsed/Refractory B-Cell Lymphoma Patient with Rapid Remission Following Chimeric Antigen Receptor T-Cell Therapy
title_full_unstemmed Delayed Terminal Ileal Perforation in a Relapsed/Refractory B-Cell Lymphoma Patient with Rapid Remission Following Chimeric Antigen Receptor T-Cell Therapy
title_short Delayed Terminal Ileal Perforation in a Relapsed/Refractory B-Cell Lymphoma Patient with Rapid Remission Following Chimeric Antigen Receptor T-Cell Therapy
title_sort delayed terminal ileal perforation in a relapsed/refractory b-cell lymphoma patient with rapid remission following chimeric antigen receptor t-cell therapy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192928/
https://www.ncbi.nlm.nih.gov/pubmed/29397660
http://dx.doi.org/10.4143/crt.2017.473
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