miR-3178 inhibits cell proliferation and metastasis by targeting Notch1 in triple-negative breast cancer

Triple-negative breast cancer (TNBC) has a poorer outcome than other subtypes of breast cancer, and the discovery of dysregulated microRNA (miRNA) and their role in tumor progression has provided a new avenue for elucidating the mechanism involved in TNBC. In this study, we identified that miR-3178...

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Autores principales: Kong, Peng, Chen, Lie, Yu, Muxin, Tao, Jing, Liu, Jiawei, Wang, Yue, Pan, Hong, Zhou, Wenbin, Wang, Shui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192997/
https://www.ncbi.nlm.nih.gov/pubmed/30333478
http://dx.doi.org/10.1038/s41419-018-1091-y
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author Kong, Peng
Chen, Lie
Yu, Muxin
Tao, Jing
Liu, Jiawei
Wang, Yue
Pan, Hong
Zhou, Wenbin
Wang, Shui
author_facet Kong, Peng
Chen, Lie
Yu, Muxin
Tao, Jing
Liu, Jiawei
Wang, Yue
Pan, Hong
Zhou, Wenbin
Wang, Shui
author_sort Kong, Peng
collection PubMed
description Triple-negative breast cancer (TNBC) has a poorer outcome than other subtypes of breast cancer, and the discovery of dysregulated microRNA (miRNA) and their role in tumor progression has provided a new avenue for elucidating the mechanism involved in TNBC. In this study, we identified that miR-3178 was significantly reduced in TNBC, and the low miR-3178 expression correlated with poor overall survival in TNBC but not in non-TNBC. The ectopic overexpression of miR-3178 suppressed TNBC cell proliferation, invasion, and migration by inhibiting the epithelial-to-mesenchymal (EMT) transition. Notch1 was validated as the direct target gene of miR-3178, which was confirmed by the dual-luciferase reporter assay. miR-3178 decreased the expression of Notch1 and restoration of Notch1 expression attenuated the inhibitory effects of miR-3178 on cell proliferation, metastasis, and the EMT in TNBC. miR-3178 inhibited cell proliferation and metastasis by targeting Notch1 in TNBC, and the restoration of miR-3178 might be a potential therapeutic strategy for TNBC.
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spelling pubmed-61929972018-10-19 miR-3178 inhibits cell proliferation and metastasis by targeting Notch1 in triple-negative breast cancer Kong, Peng Chen, Lie Yu, Muxin Tao, Jing Liu, Jiawei Wang, Yue Pan, Hong Zhou, Wenbin Wang, Shui Cell Death Dis Article Triple-negative breast cancer (TNBC) has a poorer outcome than other subtypes of breast cancer, and the discovery of dysregulated microRNA (miRNA) and their role in tumor progression has provided a new avenue for elucidating the mechanism involved in TNBC. In this study, we identified that miR-3178 was significantly reduced in TNBC, and the low miR-3178 expression correlated with poor overall survival in TNBC but not in non-TNBC. The ectopic overexpression of miR-3178 suppressed TNBC cell proliferation, invasion, and migration by inhibiting the epithelial-to-mesenchymal (EMT) transition. Notch1 was validated as the direct target gene of miR-3178, which was confirmed by the dual-luciferase reporter assay. miR-3178 decreased the expression of Notch1 and restoration of Notch1 expression attenuated the inhibitory effects of miR-3178 on cell proliferation, metastasis, and the EMT in TNBC. miR-3178 inhibited cell proliferation and metastasis by targeting Notch1 in TNBC, and the restoration of miR-3178 might be a potential therapeutic strategy for TNBC. Nature Publishing Group UK 2018-10-17 /pmc/articles/PMC6192997/ /pubmed/30333478 http://dx.doi.org/10.1038/s41419-018-1091-y Text en © The Author(s) 2018 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Kong, Peng
Chen, Lie
Yu, Muxin
Tao, Jing
Liu, Jiawei
Wang, Yue
Pan, Hong
Zhou, Wenbin
Wang, Shui
miR-3178 inhibits cell proliferation and metastasis by targeting Notch1 in triple-negative breast cancer
title miR-3178 inhibits cell proliferation and metastasis by targeting Notch1 in triple-negative breast cancer
title_full miR-3178 inhibits cell proliferation and metastasis by targeting Notch1 in triple-negative breast cancer
title_fullStr miR-3178 inhibits cell proliferation and metastasis by targeting Notch1 in triple-negative breast cancer
title_full_unstemmed miR-3178 inhibits cell proliferation and metastasis by targeting Notch1 in triple-negative breast cancer
title_short miR-3178 inhibits cell proliferation and metastasis by targeting Notch1 in triple-negative breast cancer
title_sort mir-3178 inhibits cell proliferation and metastasis by targeting notch1 in triple-negative breast cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192997/
https://www.ncbi.nlm.nih.gov/pubmed/30333478
http://dx.doi.org/10.1038/s41419-018-1091-y
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