Does the Time of Drug Administration Alter the Metabolic Risk of Aripiprazole?

Antipsychotic drugs cause metabolic abnormalities through a mechanism that involves antagonism of D(2) dopamine receptors (D(2)R). Under healthy conditions, insulin release follows a circadian rhythm and is low at night, and in pancreatic beta-cells, D(2)Rs negatively regulate insulin release. Since...

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Detalles Bibliográficos
Autores principales: Chipchura, Danielle A., Freyberg, Zachary, Edwards, Corey, Leckband, Susan G., McCarthy, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Psychiatry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193090/
https://www.ncbi.nlm.nih.gov/pubmed/30364286
http://dx.doi.org/10.3389/fpsyt.2018.00494

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