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The Regulation of AMPA Receptor Endocytosis by Dynamic Protein-Protein Interactions

The precise regulation of AMPA receptor (AMPAR) trafficking in neurons is crucial for excitatory neurotransmission, synaptic plasticity and the consequent formation and modification of neural circuits during brain development and learning. Clathrin-mediated endocytosis (CME) is an essential traffick...

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Autor principal: Hanley, Jonathan G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193100/
https://www.ncbi.nlm.nih.gov/pubmed/30364226
http://dx.doi.org/10.3389/fncel.2018.00362
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author Hanley, Jonathan G.
author_facet Hanley, Jonathan G.
author_sort Hanley, Jonathan G.
collection PubMed
description The precise regulation of AMPA receptor (AMPAR) trafficking in neurons is crucial for excitatory neurotransmission, synaptic plasticity and the consequent formation and modification of neural circuits during brain development and learning. Clathrin-mediated endocytosis (CME) is an essential trafficking event for the activity-dependent removal of AMPARs from the neuronal plasma membrane, resulting in a reduction in synaptic strength known as long-term depression (LTD). The regulated AMPAR endocytosis that underlies LTD is caused by specific modes of synaptic activity, most notably stimulation of NMDA receptors (NMDARs) and metabotropic glutamate receptors (mGluRs). Numerous proteins associate with AMPAR subunits, directly or indirectly, to control their trafficking, and therefore the regulation of these protein-protein interactions in response to NMDAR or mGluR signaling is a critical feature of synaptic plasticity. This article reviews the protein-protein interactions that are dynamically regulated during synaptic plasticity to modulate AMPAR endocytosis, focussing on AMPAR binding proteins and proteins that bind the core endocytic machinery. In addition, the mechanisms for the regulation of protein-protein interactions are considered, as well as the functional consequences of these dynamic interactions on AMPAR endocytosis.
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spelling pubmed-61931002018-10-25 The Regulation of AMPA Receptor Endocytosis by Dynamic Protein-Protein Interactions Hanley, Jonathan G. Front Cell Neurosci Neuroscience The precise regulation of AMPA receptor (AMPAR) trafficking in neurons is crucial for excitatory neurotransmission, synaptic plasticity and the consequent formation and modification of neural circuits during brain development and learning. Clathrin-mediated endocytosis (CME) is an essential trafficking event for the activity-dependent removal of AMPARs from the neuronal plasma membrane, resulting in a reduction in synaptic strength known as long-term depression (LTD). The regulated AMPAR endocytosis that underlies LTD is caused by specific modes of synaptic activity, most notably stimulation of NMDA receptors (NMDARs) and metabotropic glutamate receptors (mGluRs). Numerous proteins associate with AMPAR subunits, directly or indirectly, to control their trafficking, and therefore the regulation of these protein-protein interactions in response to NMDAR or mGluR signaling is a critical feature of synaptic plasticity. This article reviews the protein-protein interactions that are dynamically regulated during synaptic plasticity to modulate AMPAR endocytosis, focussing on AMPAR binding proteins and proteins that bind the core endocytic machinery. In addition, the mechanisms for the regulation of protein-protein interactions are considered, as well as the functional consequences of these dynamic interactions on AMPAR endocytosis. Frontiers Media S.A. 2018-10-11 /pmc/articles/PMC6193100/ /pubmed/30364226 http://dx.doi.org/10.3389/fncel.2018.00362 Text en Copyright © 2018 Hanley. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Hanley, Jonathan G.
The Regulation of AMPA Receptor Endocytosis by Dynamic Protein-Protein Interactions
title The Regulation of AMPA Receptor Endocytosis by Dynamic Protein-Protein Interactions
title_full The Regulation of AMPA Receptor Endocytosis by Dynamic Protein-Protein Interactions
title_fullStr The Regulation of AMPA Receptor Endocytosis by Dynamic Protein-Protein Interactions
title_full_unstemmed The Regulation of AMPA Receptor Endocytosis by Dynamic Protein-Protein Interactions
title_short The Regulation of AMPA Receptor Endocytosis by Dynamic Protein-Protein Interactions
title_sort regulation of ampa receptor endocytosis by dynamic protein-protein interactions
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193100/
https://www.ncbi.nlm.nih.gov/pubmed/30364226
http://dx.doi.org/10.3389/fncel.2018.00362
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