SHANK3 Downregulation in the Ventral Tegmental Area Accelerates the Extinction of Contextual Associations Induced by Juvenile Non-familiar Conspecific Interaction

Haploinsufficiency of the SHANK3 gene, encoding for a scaffolding protein located in the postsynaptic density of glutamatergic synapse, has been linked to forms of autism spectrum disorders (ASDs). It has been shown that SHANK3 controls the maturation of social reward circuits in the ventral tegment...

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Detalles Bibliográficos
Autores principales: Bariselli, Sebastiano, Contestabile, Alessandro, Tzanoulinou, Stamatina, Musardo, Stefano, Bellone, Camilla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193109/
https://www.ncbi.nlm.nih.gov/pubmed/30364266
http://dx.doi.org/10.3389/fnmol.2018.00360

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