Cargando…

Substrate Specificity Analysis of Dihydrofolate/Dihydromethanopterin Reductase Homologs in Methylotrophic α-Proteobacteria

Methane-producing archaea and methylotrophic bacteria use tetrahydromethanopterin (H(4)MPT) and/or tetrahydrofolate (H(4)F) as coenzymes in one-carbon (C1) transfer pathways. The α-proteobacterium Methylobacterium extorquens AM1 contains a dihydromethanopterin reductase (DmrA) and two annotated dihy...

Descripción completa

Detalles Bibliográficos
Autores principales:	Burton, Mark, Abanobi, Chidinma, Wang, Kate Tzu-Chi, Ma, Yihua, Rasche, Madeline E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193120/ https://www.ncbi.nlm.nih.gov/pubmed/30364315 http://dx.doi.org/10.3389/fmicb.2018.02439

Ejemplares similares

Tales of Dihydrofolate Binding to R67 Dihydrofolate Reductase
por: Duff, Michael R., et al.
Publicado: (2015)

Adaptations for Pressure and Temperature in Dihydrofolate Reductases
por: Penhallurick, Ryan W., et al.
Publicado: (2021)

Minimization of dynamic effects in the evolution of dihydrofolate reductase
por: Ruiz-Pernía, J. Javier, et al.
Publicado: (2016)

Electric Field Measurements Reveal the Pivotal Role of Cofactor–Substrate Interaction in Dihydrofolate Reductase Catalysis
por: Adesina, Aduragbemi S., et al.
Publicado: (2020)

Homology building as a means to define antigenic epitopes on dihydrofolate reductase (DHFR) from Plasmodium falciparum
por: Alifrangis, Michael, et al.
Publicado: (2004)

The Structure and Competitive Substrate Inhibition of Dihydrofolate Reductase from Enterococcus faecalis Reveal Restrictions to Cofactor Docking
por: Bourne, Christina R., et al.
Publicado: (2014)

Binding of Natural and Synthetic Polyphenols to Human Dihydrofolate Reductase
por: Sánchez-del-Campo, Luís, et al.
Publicado: (2009)

The Role of Large-Scale Motions in Catalysis by Dihydrofolate Reductase
por: Loveridge, E. Joel, et al.
Publicado: (2011)

Side Chain Conformational Averaging in Human Dihydrofolate Reductase
por: Tuttle, Lisa M., et al.
Publicado: (2014)

Divergent evolution of protein conformational dynamics in dihydrofolate reductase
por: Bhabha, Gira, et al.
Publicado: (2013)

Evolution Alters the Enzymatic Reaction Coordinate of Dihydrofolate Reductase
por: Masterson, Jean E., et al.
Publicado: (2014)

Different Dynamical Effects in Mesophilic and Hyperthermophilic Dihydrofolate Reductases
por: Luk, Louis Y. P., et al.
Publicado: (2014)

Phosphorylation of Thymidylate Synthase and Dihydrofolate Reductase in Cancer Cells and the Effect of CK2α Silencing
por: Wińska, Patrycja, et al.
Publicado: (2023)

Combined gene deletion of dihydrofolate reductase-thymidylate synthase and pteridine reductase in Leishmania infantum
por: Bhattacharya, Arijit, et al.
Publicado: (2021)

Dihydrofolate Reductase Gene Variations in Susceptibility to Disease and Treatment Outcomes
por: Askari, Bahram S., et al.
Publicado: (2010)

Dihydrofolate reductase as a model for studies of enzyme dynamics and catalysis
por: Kohen, Amnon
Publicado: (2015)

A calibration curve for immobilized dihydrofolate reductase activity assay
por: Singh, Priyanka, et al.
Publicado: (2015)

Lausannevirus Encodes a Functional Dihydrofolate Reductase Susceptible to Proguanil
por: Mueller, L., et al.
Publicado: (2017)

Hypermethylation of dihydrofolate reductase promoter increases the risk of hypertension in Chinese
por: Xu, Guodong, et al.
Publicado: (2020)

Metformin sensitises hepatocarcinoma cells to methotrexate by targeting dihydrofolate reductase
por: Wang, Yinghui, et al.
Publicado: (2021)

Computational Development of Inhibitors of Plasmid-Borne Bacterial Dihydrofolate Reductase
por: Silva, Pedro J.
Publicado: (2022)

Development and validation of a cytochrome c-coupled assay for pteridine reductase 1 and dihydrofolate reductase
por: Shanks, Emma J., et al.
Publicado: (2010)

Evidence of Pyrimethamine and Cycloguanil Analogues as Dual Inhibitors of Trypanosoma brucei Pteridine Reductase and Dihydrofolate Reductase
por: Tassone, Giusy, et al.
Publicado: (2021)

luxR Homolog-Linked Biosynthetic Gene Clusters in Proteobacteria
por: Brotherton, Carolyn A., et al.
Publicado: (2018)

Multiple origins of resistance-conferring mutations in Plasmodium vivax dihydrofolate reductase
por: Hawkins, Vivian N, et al.
Publicado: (2008)

Dihydrofolate Reductase I164L Mutation in Plasmodium falciparum, Madagascar
por: Ménard, Didier, et al.
Publicado: (2008)

Computational analysis of binding between malarial dihydrofolate reductases and anti-folates
por: Choowongkomon, Kiattawee, et al.
Publicado: (2010)

Thermal Adaptation of Dihydrofolate Reductase from the Moderate Thermophile Geobacillus stearothermophilus
por: Guo, Jiannan, et al.
Publicado: (2014)

Optimized peptide based inhibitors targeting the dihydrofolate reductase pathway in cancer
por: Singh, Amrinder, et al.
Publicado: (2018)

Molecular Docking Analysis of Pyrimethamine Derivatives with Plasmodium falciparum Dihydrofolate Reductase
por: Singh, Indra Vikram, et al.
Publicado: (2018)

Molecular Characteristics and Serodiagnostic Potential of Dihydrofolate Reductase from Echinococcus granulosus
por: Song, Xingju, et al.
Publicado: (2017)

A comparative molecular docking study of curcumin and methotrexate to dihydrofolate reductase
por: Hobani, Yahya, et al.
Publicado: (2017)

Dihydrofolate Reductase Inhibitors: The Pharmacophore as a Guide for Co-Crystal Screening
por: Baptista, João A., et al.
Publicado: (2021)

Cryo‐kinetics Reveal Dynamic Effects on the Chemistry of Human Dihydrofolate Reductase
por: Adesina, Aduragbemi S., et al.
Publicado: (2021)

Repurposing the Trypanosomatidic GSK Kinetobox for the Inhibition of Parasitic Pteridine and Dihydrofolate Reductases
por: Santucci, Matteo, et al.
Publicado: (2021)

Sesquiterpene Lactones with Dual Inhibitory Activity against the Trypanosoma brucei Pteridine Reductase 1 and Dihydrofolate Reductase
por: Possart, Katharina, et al.
Publicado: (2021)

The antimicrobial drug pyrimethamine inhibits STAT3 transcriptional activity by targeting the enzyme dihydrofolate reductase
por: Heppler, Lisa N., et al.
Publicado: (2021)

Inhibitor-bound complexes of dihydrofolate reductase-thymidylate synthase from Babesia bovis
por: Begley, Darren W., et al.
Publicado: (2011)

Fitness Trade-Offs in the Evolution of Dihydrofolate Reductase and Drug Resistance in Plasmodium falciparum
por: Costanzo, Marna S., et al.
Publicado: (2011)

Cloning and heterologous expression of Plasmodium ovale dihydrofolate reductase-thymidylate synthase gene
por: Tirakarn, Srisuda, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_k7uipp8vjlujfdlb39i1u3klkk