Ursodeoxycholic Acid Improves Mitochondrial Function and Redistributes Drp1 in Fibroblasts from Patients with Either Sporadic or Familial Alzheimer's Disease

Alzheimer's disease (AD) is the leading cause of dementia worldwide. Mitochondrial abnormalities have been identified in many cell types in AD, with deficits preceding the development of the classical pathological aggregations. Ursodeoxycholic acid (UDCA), a treatment for primary biliary cirrho...

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Detalles Bibliográficos
Autores principales: Bell, Simon M., Barnes, Katy, Clemmens, Hannah, Al-Rafiah, Aziza R., Al-ofi, Ebtisam A., Leech, Vicki, Bandmann, Oliver, Shaw, Pamela J., Blackburn, Daniel J., Ferraiuolo, Laura, Mortiboys, Heather
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193139/
https://www.ncbi.nlm.nih.gov/pubmed/30171839
http://dx.doi.org/10.1016/j.jmb.2018.08.019

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