Cargando…

Treatment With Nilvadipine Mitigates Inflammatory Pathology and Improves Spatial Memory in Aged hTau Mice After Repetitive Mild TBI

Mild traumatic brain injury (mTBI) is the most common form of brain trauma worldwide. The effects of mTBI are not well-studied within the elderly population, yet older adults constitute a significant portion of all mTBI patients. Few preclinical studies have focused on the effects of mTBI, or mTBI t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Morin, Alexander, Mouzon, Benoit, Ferguson, Scott, Paris, Daniel, Saltiel, Nicole, Lungmus, Carlyn, Mullan, Mike, Crawford, Fiona
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193195/ https://www.ncbi.nlm.nih.gov/pubmed/30364309 http://dx.doi.org/10.3389/fnagi.2018.00292

Ejemplares similares

Nilvadipine suppresses inflammation via inhibition of P-SYK and restores spatial memory deficits in a mouse model of repetitive mild TBI
por: Morin, Alexander, et al.
Publicado: (2020)

A 3-month-delayed treatment with anatabine improves chronic outcomes in two different models of repetitive mild traumatic brain injury in hTau mice
por: Morin, Alexander, et al.
Publicado: (2021)

Negative Impact of Female Sex on Outcomes from Repetitive Mild Traumatic Brain Injury in hTau Mice Is Age Dependent: A Chronic Effects of Neurotrauma Consortium Study
por: Ferguson, Scott A., et al.
Publicado: (2017)

Mural cell dysfunction leads to altered cerebrovascular tau uptake following repetitive head trauma
por: Ojo, Joseph, et al.
Publicado: (2020)

Unbiased Proteomic Approach Identifies Unique and Coincidental Plasma Biomarkers in Repetitive mTBI and AD Pathogenesis
por: Ojo, Joseph O., et al.
Publicado: (2018)

Disruption in Brain Phospholipid Content in a Humanized Tau Transgenic Model Following Repetitive Mild Traumatic Brain Injury
por: Ojo, Joseph O., et al.
Publicado: (2018)

Oleoylethanolamide treatment reduces neurobehavioral deficits and brain pathology in a mouse model of Gulf War Illness
por: Joshi, Utsav, et al.
Publicado: (2018)

Author Correction: Oleoylethanolamide treatment reduces neurobehavioral deficits and brain pathology in a mouse model of Gulf War Illness
por: Joshi, Utsav, et al.
Publicado: (2019)

Constant Levels of Tau Phosphorylation in the Brain of htau Mice
por: Neddens, Joerg, et al.
Publicado: (2020)

Lifelong behavioral and neuropathological consequences of repetitive mild traumatic brain injury
por: Mouzon, Benoit C., et al.
Publicado: (2017)

Nilvadipine in mild to moderate Alzheimer disease: A randomised controlled trial
por: Lawlor, Brian, et al.
Publicado: (2018)

Chronic Hippocampal Abnormalities and Blunted HPA Axis in an Animal Model of Repeated Unpredictable Stress
por: Algamal, Moustafa, et al.
Publicado: (2018)

Insulin deprivation induces PP2A inhibition and tau hyperphosphorylation in hTau mice, a model of Alzheimer’s disease-like tau pathology
por: Gratuze, Maud, et al.
Publicado: (2017)

Converging and Differential Brain Phospholipid Dysregulation in the Pathogenesis of Repetitive Mild Traumatic Brain Injury and Alzheimer’s Disease
por: Ojo, Joseph O., et al.
Publicado: (2019)

Codonopsis pilosula Polysaccharide Attenuates Tau Hyperphosphorylation and Cognitive Impairments in hTau Infected Mice
por: Zhang, Qing, et al.
Publicado: (2018)

Sub-Chronic Neuropathological and Biochemical Changes in Mouse Visual System after Repetitive Mild Traumatic Brain Injury
por: Tzekov, Radouil, et al.
Publicado: (2016)

P301S‐hTau acetylates KEAP1 to trigger synaptic toxicity via inhibiting NRF2/ARE pathway: A novel mechanism underlying hTau‐induced synaptic toxicities
por: Xie, Jia‐Zhao, et al.
Publicado: (2022)

NILVAD protocol: a European multicentre double-blind placebo-controlled trial of nilvadipine in mild-to-moderate Alzheimer's disease
por: Lawlor, Brian, et al.
Publicado: (2014)

Induction of Oxidative Stress in SH-SY5Y Cells by Overexpression of hTau40 and Its Mitigation by Redox-Active Nanoparticles
por: Pieńkowska, Natalia, et al.
Publicado: (2022)

In Vivo Validation of a Small Molecule Inhibitor of Tau Self-Association in htau Mice
por: Davidowitz, Eliot J., et al.
Publicado: (2020)

Influence of traumatic brain injury on extracellular tau elimination at the blood–brain barrier
por: Eisenbaum, Maxwell, et al.
Publicado: (2021)

Unbiased Proteomic Approach Identifies Pathobiological Profiles in the Brains of Preclinical Models of Repetitive Mild Traumatic Brain Injury, Tauopathy, and Amyloidosis
por: Ojo, Joseph O., et al.
Publicado: (2020)

Dysregulated Brain Protein Phosphorylation Linked to Increased Human Tau Expression in the hTau Transgenic Mouse Model
por: Ferrer, Isidro, et al.
Publicado: (2022)

Human amnionic progenitor cell secretome mitigates the consequence of traumatic optic neuropathy in a mouse model
por: McCartan, Robyn, et al.
Publicado: (2023)

Subacute and chronic proteomic and phosphoproteomic analyses of a mouse model of traumatic brain injury at two timepoints and comparison with chronic traumatic encephalopathy in human samples
por: Morin, Alexander, et al.
Publicado: (2022)

Sirt1 enhances tau exon 10 inclusion and improves spatial memory of Htau mice
por: Qian, Shuo, et al.
Publicado: (2018)

Neuroradiological Changes Following Single or Repetitive Mild TBI
por: Kulkarni, Praveen, et al.
Publicado: (2019)

Increasing Tau 4R Tau Levels Exacerbates Hippocampal Tau Hyperphosphorylation in the hTau Model of Tauopathy but Also Tau Dephosphorylation Following Acute Systemic Inflammation
por: Barron, Matthew R., et al.
Publicado: (2020)

Expression of P301L-hTau in mouse MEC induces hippocampus-dependent memory deficit
por: Liu, Xinghua, et al.
Publicado: (2017)

Irisin treatment lowers levels of phosphorylated tau in the hippocampus of pre‐symptomatic female but not male htau mice
por: Bretland, Katie A., et al.
Publicado: (2021)

Factors other than hTau overexpression that contribute to tauopathy-like phenotype in rTg4510 mice
por: Gamache, Julia, et al.
Publicado: (2019)

Knock-in of Mutated hTAU Causes Insulin Resistance, Inflammation and Proteostasis Disturbance in a Mouse Model of Frontotemporal Dementia
por: Hull, Claire, et al.
Publicado: (2019)

Common and Specific Marks of Different Tau Strains Following Intra-Hippocampal Injection of AD, PiD, and GGT Inoculum in hTau Transgenic Mice
por: Ferrer, Isidro, et al.
Publicado: (2022)

Repetitive mild TBI causes pTau aggregation in nigra without altering preexisting fibril induced Parkinson’s-like pathology burden
por: Delic, Vedad, et al.
Publicado: (2022)

Impact of gulf war toxic exposures after mild traumatic brain injury
por: Ferguson, Scott, et al.
Publicado: (2022)

Ophthalmic Formulation Containing Nilvadipine Nanoparticles Prevents Retinal Dysfunction in Rats Injected with Streptozotocin
por: Deguchi, Saori, et al.
Publicado: (2017)

Combination of Lanosterol and Nilvadipine Nanosuspensions Rescues Lens Opacification in Selenite-Induced Cataractic Rats
por: Deguchi, Saori, et al.
Publicado: (2022)

Blood Pressure Lowering With Nilvadipine in Patients With Mild‐to‐Moderate Alzheimer Disease Does Not Increase the Prevalence of Orthostatic Hypotension
por: de Heus, Rianne A. A., et al.
Publicado: (2019)

Alzheimer’s disease pathological lesions activate the spleen tyrosine kinase
por: Schweig, Jonas Elias, et al.
Publicado: (2017)

Impaired burrowing is the most prominent behavioral deficit of aging htau mice
por: Geiszler, Philippine Camilla, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_o3jat5ql570015nbhas6pkapjv