Rapid Continuous Ruthenium-Catalysed Transfer Hydrogenation of Aromatic Nitriles to Primary Amines

A continuous flow method for the selective reduction of aromatic nitriles to the corresponding amine is reported. The method is based on a ruthenium-catalysed transfer-hydrogenation process, requires no additives, and uses isopropanol as both solvent and reducing agent. The process utilizes 1 mol% o...

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Detalles Bibliográficos
Autores principales: Labes, Ricardo, González-Calderón, Davir, Battilocchio, Claudio, Mateos, Carlos, Cumming, Graham R., de Frutos, Oscar, Rincón, Juan A., Ley, Steven V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: © Georg Thieme Verlag 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193226/
http://dx.doi.org/10.1055/s-0036-1589096

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