CRISPR-induced exon skipping is dependent on premature termination codon mutations

In previous studies, CRISPR/Cas9 was shown to induce unexpected exon skipping; however, the mechanism by which this phenomenon is triggered is controversial. By analyzing 22 gene-edited rabbit lines generated using CRISPR/Cas9, we provide evidence of exon skipping at high frequency in premature term...

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Detalles Bibliográficos
Autores principales: Sui, Tingting, Song, Yuning, Liu, Zhiquan, Chen, Mao, Deng, Jichao, Xu, Yuanyuan, Lai, Liangxue, Li, Zhanjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193291/
https://www.ncbi.nlm.nih.gov/pubmed/30333044
http://dx.doi.org/10.1186/s13059-018-1532-z

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