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Biocompatible Carbon-Based Coating as Potential Endovascular Material for Stent Surface

Stainless steel 316L is a material commonly used in cardiovascular medicine. Despite the various methods applied in stent production, the rates of in-stent restenosis and thrombosis remain high. In this study graphene was used to coat the surface of 316L substrate for enhanced bio- and hemocompatibi...

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Detalles Bibliográficos
Autores principales: Wawrzyńska, Magdalena, Bil-Lula, Iwona, Krzywonos-Zawadzka, Anna, Arkowski, Jacek, Łukaszewicz, Mikołaj, Hreniak, Dariusz, Stręk, Wiesław, Sawicki, Grzegorz, Woźniak, Mieczysław, Drab, Marek, Frączkowska, Kaja, Duda, Maciej, Kopaczyńska, Marta, Podbielska, Halina, Biały, Dariusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193326/
https://www.ncbi.nlm.nih.gov/pubmed/30402466
http://dx.doi.org/10.1155/2018/2758347
Descripción
Sumario:Stainless steel 316L is a material commonly used in cardiovascular medicine. Despite the various methods applied in stent production, the rates of in-stent restenosis and thrombosis remain high. In this study graphene was used to coat the surface of 316L substrate for enhanced bio- and hemocompatibility of the substrate. The presence of graphene layers applied to the substrate was investigated using cutting-edge imaging technology: energy-filtered low-voltage FE-SEM approach, scanning electron microscopy (SEM), Raman spectroscopy, and atomic force microscopy (AFM). The potential of G-316L surface to influence endothelial cells phenotype and endothelial-to-mesenchymal transition (EndoMT) has been determined. Our results show that the bio- and hemocompatible properties of graphene coatings along with known radial force of 316L make G-316L a promising candidate for intracoronary implants.