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Diverse Expression of IL-32 in Diffuse and Intestinal Types of Gastric Cancer
INTRODUCTION: Gastric cancer (GC) represents one of the most common cancers worldwide, frequently diagnosed at advanced stages with poor prognosis, indicating on need for new diagnostic and prognostic markers. The aim of the study was to determine the expression of IL-32, proinflammatory and angioge...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193340/ https://www.ncbi.nlm.nih.gov/pubmed/30402092 http://dx.doi.org/10.1155/2018/6578273 |
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author | Pavlovic, Mladen Gajovic, Nevena Jurisevic, Milena Mitrovic, Slobodanka Radosavljevic, Gordana Pantic, Jelena Arsenijevic, Nebojsa Jovanovic, Ivan |
author_facet | Pavlovic, Mladen Gajovic, Nevena Jurisevic, Milena Mitrovic, Slobodanka Radosavljevic, Gordana Pantic, Jelena Arsenijevic, Nebojsa Jovanovic, Ivan |
author_sort | Pavlovic, Mladen |
collection | PubMed |
description | INTRODUCTION: Gastric cancer (GC) represents one of the most common cancers worldwide, frequently diagnosed at advanced stages with poor prognosis, indicating on need for new diagnostic and prognostic markers. The aim of the study was to determine the expression of IL-32, proinflammatory and angiogenic mediators, in patients with diffuse and intestinal gastric cancer and the relationship with clinicopathological aspects. MATERIAL AND METHODS: The tissue samples of diffuse and intestinal types of tumor of 70 patients with gastric cancer were analyzed. Expression of IL-32, VEGF, IL-17, and CD31 was measured by immunohistochemistry. RESULTS: IL-32 expression was significantly lower in tissue samples from patients with diffuse type of gastric cancer that is also a severe and more progressive form (TNM stages III and IV, poor histological differentiation, and higher nuclear grade III). Expression of IL-17 was also decreased in patients with diffuse type of gastric cancer. Microvascular density was diminished in diffuse type of gastric cancer. CONCLUSIONS: Downregulated expression of IL-32 in tumor tissue of patients with diffuse type of gastric cancer may implicate on its role in limiting ongoing proinflammatory and proangiogenic processes. This emphasizes on unrecognized role of IL-32 in biology of diffuse type of gastric cancer. |
format | Online Article Text |
id | pubmed-6193340 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-61933402018-11-06 Diverse Expression of IL-32 in Diffuse and Intestinal Types of Gastric Cancer Pavlovic, Mladen Gajovic, Nevena Jurisevic, Milena Mitrovic, Slobodanka Radosavljevic, Gordana Pantic, Jelena Arsenijevic, Nebojsa Jovanovic, Ivan Gastroenterol Res Pract Research Article INTRODUCTION: Gastric cancer (GC) represents one of the most common cancers worldwide, frequently diagnosed at advanced stages with poor prognosis, indicating on need for new diagnostic and prognostic markers. The aim of the study was to determine the expression of IL-32, proinflammatory and angiogenic mediators, in patients with diffuse and intestinal gastric cancer and the relationship with clinicopathological aspects. MATERIAL AND METHODS: The tissue samples of diffuse and intestinal types of tumor of 70 patients with gastric cancer were analyzed. Expression of IL-32, VEGF, IL-17, and CD31 was measured by immunohistochemistry. RESULTS: IL-32 expression was significantly lower in tissue samples from patients with diffuse type of gastric cancer that is also a severe and more progressive form (TNM stages III and IV, poor histological differentiation, and higher nuclear grade III). Expression of IL-17 was also decreased in patients with diffuse type of gastric cancer. Microvascular density was diminished in diffuse type of gastric cancer. CONCLUSIONS: Downregulated expression of IL-32 in tumor tissue of patients with diffuse type of gastric cancer may implicate on its role in limiting ongoing proinflammatory and proangiogenic processes. This emphasizes on unrecognized role of IL-32 in biology of diffuse type of gastric cancer. Hindawi 2018-10-04 /pmc/articles/PMC6193340/ /pubmed/30402092 http://dx.doi.org/10.1155/2018/6578273 Text en Copyright © 2018 Mladen Pavlovic et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Pavlovic, Mladen Gajovic, Nevena Jurisevic, Milena Mitrovic, Slobodanka Radosavljevic, Gordana Pantic, Jelena Arsenijevic, Nebojsa Jovanovic, Ivan Diverse Expression of IL-32 in Diffuse and Intestinal Types of Gastric Cancer |
title | Diverse Expression of IL-32 in Diffuse and Intestinal Types of Gastric Cancer |
title_full | Diverse Expression of IL-32 in Diffuse and Intestinal Types of Gastric Cancer |
title_fullStr | Diverse Expression of IL-32 in Diffuse and Intestinal Types of Gastric Cancer |
title_full_unstemmed | Diverse Expression of IL-32 in Diffuse and Intestinal Types of Gastric Cancer |
title_short | Diverse Expression of IL-32 in Diffuse and Intestinal Types of Gastric Cancer |
title_sort | diverse expression of il-32 in diffuse and intestinal types of gastric cancer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193340/ https://www.ncbi.nlm.nih.gov/pubmed/30402092 http://dx.doi.org/10.1155/2018/6578273 |
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