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Use of domperidone in canine visceral leishmaniasis: gaps in veterinary knowledge and epidemiological implications
A pivotal strategy to decrease the risk of visceral leishmaniasis in humans is to control the infection and disease progression in dogs, the domestic reservoir of Leishmania infantum (L. chagasi). Immunotherapy is a viable approach to treat sick dogs because cell-mediated immunity is the principal d...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Instituto Oswaldo Cruz, Ministério da Saúde
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193371/ https://www.ncbi.nlm.nih.gov/pubmed/30365645 http://dx.doi.org/10.1590/0074-02760180301 |
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author | Travi, Bruno L Miró, Guadalupe |
author_facet | Travi, Bruno L Miró, Guadalupe |
author_sort | Travi, Bruno L |
collection | PubMed |
description | A pivotal strategy to decrease the risk of visceral leishmaniasis in humans is to control the infection and disease progression in dogs, the domestic reservoir of Leishmania infantum (L. chagasi). Immunotherapy is a viable approach to treat sick dogs because cell-mediated immunity is the principal defense mechanism against L. infantum. Domperidone is an immune-stimulatory drug increasingly used in veterinary medicine as a prophylactic or immunotherapeutic agent. Domperidone treatment has shown to prevent overt disease or improve the clinical condition of infected dogs. However, veterinarians should be aware of the potential cardiotoxicity of domperidone when given together with drugs that inhibit CYP450s liver enzymes or those that prolong the QT interval. On the other hand, learning whether domperidone treatment significantly decreases dog infectivity to sand fly vectors is of capital importance since this result should have a palpable impact on the infection risk of humans living in regions endemic for visceral leishmaniasis. |
format | Online Article Text |
id | pubmed-6193371 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Instituto Oswaldo Cruz, Ministério da Saúde |
record_format | MEDLINE/PubMed |
spelling | pubmed-61933712018-10-19 Use of domperidone in canine visceral leishmaniasis: gaps in veterinary knowledge and epidemiological implications Travi, Bruno L Miró, Guadalupe Mem Inst Oswaldo Cruz Perspective A pivotal strategy to decrease the risk of visceral leishmaniasis in humans is to control the infection and disease progression in dogs, the domestic reservoir of Leishmania infantum (L. chagasi). Immunotherapy is a viable approach to treat sick dogs because cell-mediated immunity is the principal defense mechanism against L. infantum. Domperidone is an immune-stimulatory drug increasingly used in veterinary medicine as a prophylactic or immunotherapeutic agent. Domperidone treatment has shown to prevent overt disease or improve the clinical condition of infected dogs. However, veterinarians should be aware of the potential cardiotoxicity of domperidone when given together with drugs that inhibit CYP450s liver enzymes or those that prolong the QT interval. On the other hand, learning whether domperidone treatment significantly decreases dog infectivity to sand fly vectors is of capital importance since this result should have a palpable impact on the infection risk of humans living in regions endemic for visceral leishmaniasis. Instituto Oswaldo Cruz, Ministério da Saúde 2018-10-18 /pmc/articles/PMC6193371/ /pubmed/30365645 http://dx.doi.org/10.1590/0074-02760180301 Text en https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License |
spellingShingle | Perspective Travi, Bruno L Miró, Guadalupe Use of domperidone in canine visceral leishmaniasis: gaps in veterinary knowledge and epidemiological implications |
title | Use of domperidone in canine visceral leishmaniasis: gaps in veterinary knowledge and epidemiological implications |
title_full | Use of domperidone in canine visceral leishmaniasis: gaps in veterinary knowledge and epidemiological implications |
title_fullStr | Use of domperidone in canine visceral leishmaniasis: gaps in veterinary knowledge and epidemiological implications |
title_full_unstemmed | Use of domperidone in canine visceral leishmaniasis: gaps in veterinary knowledge and epidemiological implications |
title_short | Use of domperidone in canine visceral leishmaniasis: gaps in veterinary knowledge and epidemiological implications |
title_sort | use of domperidone in canine visceral leishmaniasis: gaps in veterinary knowledge and epidemiological implications |
topic | Perspective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193371/ https://www.ncbi.nlm.nih.gov/pubmed/30365645 http://dx.doi.org/10.1590/0074-02760180301 |
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