Cardiac leptin overexpression in the context of acute MI and reperfusion potentiates myocardial remodeling and left ventricular dysfunction

BACKGROUND: Acute MI induces leptin expression in the heart, however the role of myocardial leptin in cardiac ischemia and reperfusion (IR) remains unknown. To shed light on the effects of elevated levels of leptin in the myocardium, we overexpressed cardiac leptin and assessed local remodeling and...

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Detalles Bibliográficos
Autores principales: Kain, David, Simon, Amos J., Greenberg, Avraham, Ben Zvi, Danny, Gilburd, Boris, Schneiderman, Jacob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193573/
https://www.ncbi.nlm.nih.gov/pubmed/30312306
http://dx.doi.org/10.1371/journal.pone.0203902

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