Preservation of myocardial contractility during acute hypoxia with OMX-CV, a novel oxygen delivery biotherapeutic

The heart exhibits the highest basal oxygen (O(2)) consumption per tissue mass of any organ in the body and is uniquely dependent on aerobic metabolism to sustain contractile function. During acute hypoxic states, the body responds with a compensatory increase in cardiac output that further increase...

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Detalles Bibliográficos
Autores principales: Boehme, Jason, Le Moan, Natacha, Kameny, Rebecca J., Loucks, Alexandra, Johengen, Michael J., Lesneski, Amy L., Gong, Wenhui, Goudy, Brian D., Davis, Tina, Tanaka, Kevin, Davis, Andrew, He, Youping, Long-Boyle, Janel, Ivaturi, Vijay, Gobburu, Jogarao V. S., Winger, Jonathan A., Cary, Stephen P., Datar, Sanjeev A., Fineman, Jeffrey R., Krtolica, Ana, Maltepe, Emin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Short Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193608/
https://www.ncbi.nlm.nih.gov/pubmed/30335746
http://dx.doi.org/10.1371/journal.pbio.2005924

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