cGMP production of astatine-211-labeled anti-CD45 antibodies for use in allogeneic hematopoietic cell transplantation for treatment of advanced hematopoietic malignancies

The objective of this study was to translate reaction conditions and quality control methods used for production of an astatine-211((211)At)-labeled anti-CD45 monoclonal antibody (MAb) conjugate, (211)At-BC8-B10, from the laboratory setting to cGMP production. Five separate materials were produced i...

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Detalles Bibliográficos
Autores principales: Li, Yawen, Hamlin, Donald K., Chyan, Ming-Kuan, Wong, Roger, Dorman, Eric F., Emery, Robert C., Woodle, Douglas R., Manger, Ronald L., Nartea, Margaret, Kenoyer, Aimee L., Orozco, Johnnie J., Green, Damian J., Press, Oliver W., Storb, Rainer, Sandmaier, Brenda M., Wilbur, D. Scott
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193629/
https://www.ncbi.nlm.nih.gov/pubmed/30335787
http://dx.doi.org/10.1371/journal.pone.0205135

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