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Importance of diphthamide modified EF2 for translational accuracy and competitive cell growth in yeast

In eukaryotes, the modification of an invariant histidine (His-699 in yeast) residue in translation elongation factor 2 (EF2) with diphthamide involves a conserved pathway encoded by the DPH1-DPH7 gene network. Diphthamide is the target for diphtheria toxin and related lethal ADP ribosylases, which...

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Detalles Bibliográficos
Autores principales:	Hawer, Harmen, Ütkür, Koray, Arend, Meike, Mayer, Klaus, Adrian, Lorenz, Brinkmann, Ulrich, Schaffrath, Raffael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193676/ https://www.ncbi.nlm.nih.gov/pubmed/30335802 http://dx.doi.org/10.1371/journal.pone.0205870

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