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Chromosome 19 miRNA cluster and CEBPB expression specifically mark and potentially drive triple negative breast cancers

Triple negative breast cancers (TNBCs) are known to express low PGR, ESR1, and ERBB2, and high KRT5, KRT14, and KRT17. However, the reasons behind the increased expressions of KRT5, KRT14, KRT17 and decreased expressions of PGR, ESR1, and ERBB2 in TNBCs are not fully understood. Here we show that, e...

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Detalles Bibliográficos
Autores principales: Jinesh, Goodwin G., Flores, Elsa R., Brohl, Andrew S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193703/
https://www.ncbi.nlm.nih.gov/pubmed/30335837
http://dx.doi.org/10.1371/journal.pone.0206008
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author Jinesh, Goodwin G.
Flores, Elsa R.
Brohl, Andrew S.
author_facet Jinesh, Goodwin G.
Flores, Elsa R.
Brohl, Andrew S.
author_sort Jinesh, Goodwin G.
collection PubMed
description Triple negative breast cancers (TNBCs) are known to express low PGR, ESR1, and ERBB2, and high KRT5, KRT14, and KRT17. However, the reasons behind the increased expressions of KRT5, KRT14, KRT17 and decreased expressions of PGR, ESR1, and ERBB2 in TNBCs are not fully understood. Here we show that, expression of chromosome 19 miRNA cluster (C19MC) specifically marks human TNBCs. Low REST and high CEBPB correlate with expression of C19MC, KRT5, KRT14, and KRT17 and enhancers of these genes/cluster are regulated by CEBPB and REST binding sites. The C19MC miRNAs in turn can potentially target REST to offer a positive feedback loop, and might target PGR, ESR1, ERBB2, GATA3, SCUBE2, TFF3 mRNAs to contribute towards TNBC phenotype. Thus our study demonstrates that C19MC miRNA expression marks TNBCs and that C19MC miRNAs and CEBPB might together determine the TNBC marker expression pattern.
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spelling pubmed-61937032018-11-05 Chromosome 19 miRNA cluster and CEBPB expression specifically mark and potentially drive triple negative breast cancers Jinesh, Goodwin G. Flores, Elsa R. Brohl, Andrew S. PLoS One Research Article Triple negative breast cancers (TNBCs) are known to express low PGR, ESR1, and ERBB2, and high KRT5, KRT14, and KRT17. However, the reasons behind the increased expressions of KRT5, KRT14, KRT17 and decreased expressions of PGR, ESR1, and ERBB2 in TNBCs are not fully understood. Here we show that, expression of chromosome 19 miRNA cluster (C19MC) specifically marks human TNBCs. Low REST and high CEBPB correlate with expression of C19MC, KRT5, KRT14, and KRT17 and enhancers of these genes/cluster are regulated by CEBPB and REST binding sites. The C19MC miRNAs in turn can potentially target REST to offer a positive feedback loop, and might target PGR, ESR1, ERBB2, GATA3, SCUBE2, TFF3 mRNAs to contribute towards TNBC phenotype. Thus our study demonstrates that C19MC miRNA expression marks TNBCs and that C19MC miRNAs and CEBPB might together determine the TNBC marker expression pattern. Public Library of Science 2018-10-18 /pmc/articles/PMC6193703/ /pubmed/30335837 http://dx.doi.org/10.1371/journal.pone.0206008 Text en © 2018 Jinesh et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Jinesh, Goodwin G.
Flores, Elsa R.
Brohl, Andrew S.
Chromosome 19 miRNA cluster and CEBPB expression specifically mark and potentially drive triple negative breast cancers
title Chromosome 19 miRNA cluster and CEBPB expression specifically mark and potentially drive triple negative breast cancers
title_full Chromosome 19 miRNA cluster and CEBPB expression specifically mark and potentially drive triple negative breast cancers
title_fullStr Chromosome 19 miRNA cluster and CEBPB expression specifically mark and potentially drive triple negative breast cancers
title_full_unstemmed Chromosome 19 miRNA cluster and CEBPB expression specifically mark and potentially drive triple negative breast cancers
title_short Chromosome 19 miRNA cluster and CEBPB expression specifically mark and potentially drive triple negative breast cancers
title_sort chromosome 19 mirna cluster and cebpb expression specifically mark and potentially drive triple negative breast cancers
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193703/
https://www.ncbi.nlm.nih.gov/pubmed/30335837
http://dx.doi.org/10.1371/journal.pone.0206008
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