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Association of endothelial nitric oxide synthase (eNOS) gene polymorphisms and physical fitness levels with plasma nitrite concentrations and arterial blood pressure values in older adults
Endothelial nitric oxide synthase (eNOS) gene polymorphisms are associated with reduced eNOS activity and nitric oxide (NO) production leading to an increase in blood pressure (BP). Regular exercise is the main strategy to minimize the deleterious effects of polymorphisms. However, due to the differ...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193729/ https://www.ncbi.nlm.nih.gov/pubmed/30335864 http://dx.doi.org/10.1371/journal.pone.0206254 |
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author | da Silva, Roberta Fernanda Trapé, Átila Alexandre Reia, Thaís Amanda Lacchini, Riccardo Oliveira-Paula, Gustavo Henrique Pinheiro, Lucas Cezar Tanus-Santos, José Eduardo Jacomini, André Mourão Bueno Júnior, Carlos Roberto Zago, Anderson Saranz |
author_facet | da Silva, Roberta Fernanda Trapé, Átila Alexandre Reia, Thaís Amanda Lacchini, Riccardo Oliveira-Paula, Gustavo Henrique Pinheiro, Lucas Cezar Tanus-Santos, José Eduardo Jacomini, André Mourão Bueno Júnior, Carlos Roberto Zago, Anderson Saranz |
author_sort | da Silva, Roberta Fernanda |
collection | PubMed |
description | Endothelial nitric oxide synthase (eNOS) gene polymorphisms are associated with reduced eNOS activity and nitric oxide (NO) production leading to an increase in blood pressure (BP). Regular exercise is the main strategy to minimize the deleterious effects of polymorphisms. However, due to the differences that physical exercise can be performed, some controversial results are found. Therefore it seems reasonable to evaluate the training status (TS). Thus, this study aimed to investigate the association of eNOS gene haplotypes and different levels of TS on nitrite concentrations (NO2-) and BP values in older adult. 424 elderly performed the following assessments: General Functional Fitness Index (GFFI) to estimate TS, systolic and diastolic blood pressure (SBP and DBP), blood collection for analysis of NO2- and g.-786T>C, intron 4b/a (VNTR) and 894G>T polymorphisms. Multivariate logistic regression showed that NO2- was influenced by GFFI and 4b/4a Intron 4. Regarding BP, GFFI influenced SBP and DBP, and just intron 4 was associated with variations in DBP. It can be observed that GFFI affected the NO2-, SBP and DBP independently of haplotypes. Therefore, maintenance of good level of TS can overcome the negative influence of genetics factors (intron 4) by increasing NO2- concentration and decreasing BP values. |
format | Online Article Text |
id | pubmed-6193729 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-61937292018-11-05 Association of endothelial nitric oxide synthase (eNOS) gene polymorphisms and physical fitness levels with plasma nitrite concentrations and arterial blood pressure values in older adults da Silva, Roberta Fernanda Trapé, Átila Alexandre Reia, Thaís Amanda Lacchini, Riccardo Oliveira-Paula, Gustavo Henrique Pinheiro, Lucas Cezar Tanus-Santos, José Eduardo Jacomini, André Mourão Bueno Júnior, Carlos Roberto Zago, Anderson Saranz PLoS One Research Article Endothelial nitric oxide synthase (eNOS) gene polymorphisms are associated with reduced eNOS activity and nitric oxide (NO) production leading to an increase in blood pressure (BP). Regular exercise is the main strategy to minimize the deleterious effects of polymorphisms. However, due to the differences that physical exercise can be performed, some controversial results are found. Therefore it seems reasonable to evaluate the training status (TS). Thus, this study aimed to investigate the association of eNOS gene haplotypes and different levels of TS on nitrite concentrations (NO2-) and BP values in older adult. 424 elderly performed the following assessments: General Functional Fitness Index (GFFI) to estimate TS, systolic and diastolic blood pressure (SBP and DBP), blood collection for analysis of NO2- and g.-786T>C, intron 4b/a (VNTR) and 894G>T polymorphisms. Multivariate logistic regression showed that NO2- was influenced by GFFI and 4b/4a Intron 4. Regarding BP, GFFI influenced SBP and DBP, and just intron 4 was associated with variations in DBP. It can be observed that GFFI affected the NO2-, SBP and DBP independently of haplotypes. Therefore, maintenance of good level of TS can overcome the negative influence of genetics factors (intron 4) by increasing NO2- concentration and decreasing BP values. Public Library of Science 2018-10-18 /pmc/articles/PMC6193729/ /pubmed/30335864 http://dx.doi.org/10.1371/journal.pone.0206254 Text en © 2018 da Silva et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article da Silva, Roberta Fernanda Trapé, Átila Alexandre Reia, Thaís Amanda Lacchini, Riccardo Oliveira-Paula, Gustavo Henrique Pinheiro, Lucas Cezar Tanus-Santos, José Eduardo Jacomini, André Mourão Bueno Júnior, Carlos Roberto Zago, Anderson Saranz Association of endothelial nitric oxide synthase (eNOS) gene polymorphisms and physical fitness levels with plasma nitrite concentrations and arterial blood pressure values in older adults |
title | Association of endothelial nitric oxide synthase (eNOS) gene polymorphisms and physical fitness levels with plasma nitrite concentrations and arterial blood pressure values in older adults |
title_full | Association of endothelial nitric oxide synthase (eNOS) gene polymorphisms and physical fitness levels with plasma nitrite concentrations and arterial blood pressure values in older adults |
title_fullStr | Association of endothelial nitric oxide synthase (eNOS) gene polymorphisms and physical fitness levels with plasma nitrite concentrations and arterial blood pressure values in older adults |
title_full_unstemmed | Association of endothelial nitric oxide synthase (eNOS) gene polymorphisms and physical fitness levels with plasma nitrite concentrations and arterial blood pressure values in older adults |
title_short | Association of endothelial nitric oxide synthase (eNOS) gene polymorphisms and physical fitness levels with plasma nitrite concentrations and arterial blood pressure values in older adults |
title_sort | association of endothelial nitric oxide synthase (enos) gene polymorphisms and physical fitness levels with plasma nitrite concentrations and arterial blood pressure values in older adults |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193729/ https://www.ncbi.nlm.nih.gov/pubmed/30335864 http://dx.doi.org/10.1371/journal.pone.0206254 |
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