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Global genetic diversity of var2csa in Plasmodium falciparum with implications for malaria in pregnancy and vaccine development
Malaria infection during pregnancy, caused by the sequestering of Plasmodium falciparum parasites in the placenta, leads to high infant mortality and maternal morbidity. The parasite-placenta adherence mechanism is mediated by the VAR2CSA protein, a target for natural occurring immunity. Currently,...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193930/ https://www.ncbi.nlm.nih.gov/pubmed/30337594 http://dx.doi.org/10.1038/s41598-018-33767-3 |
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author | Benavente, Ernest Diez Oresegun, Damilola R. de Sessions, Paola Florez Walker, Eloise M. Roper, Cally Dombrowski, Jamille G. de Souza, Rodrigo M. Marinho, Claudio R. F. Sutherland, Colin J. Hibberd, Martin L. Mohareb, Fady Baker, David A. Clark, Taane G. Campino, Susana |
author_facet | Benavente, Ernest Diez Oresegun, Damilola R. de Sessions, Paola Florez Walker, Eloise M. Roper, Cally Dombrowski, Jamille G. de Souza, Rodrigo M. Marinho, Claudio R. F. Sutherland, Colin J. Hibberd, Martin L. Mohareb, Fady Baker, David A. Clark, Taane G. Campino, Susana |
author_sort | Benavente, Ernest Diez |
collection | PubMed |
description | Malaria infection during pregnancy, caused by the sequestering of Plasmodium falciparum parasites in the placenta, leads to high infant mortality and maternal morbidity. The parasite-placenta adherence mechanism is mediated by the VAR2CSA protein, a target for natural occurring immunity. Currently, vaccine development is based on its ID1-DBL2Xb domain however little is known about the global genetic diversity of the encoding var2csa gene, which could influence vaccine efficacy. In a comprehensive analysis of the var2csa gene in >2,000 P. falciparum field isolates across 23 countries, we found that var2csa is duplicated in high prevalence (>25%), African and Oceanian populations harbour a much higher diversity than other regions, and that insertions/deletions are abundant leading to an underestimation of the diversity of the locus. Further, ID1-DBL2Xb haplotypes associated with adverse birth outcomes are present globally, and African-specific haplotypes exist, which should be incorporated into vaccine design. |
format | Online Article Text |
id | pubmed-6193930 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-61939302018-10-23 Global genetic diversity of var2csa in Plasmodium falciparum with implications for malaria in pregnancy and vaccine development Benavente, Ernest Diez Oresegun, Damilola R. de Sessions, Paola Florez Walker, Eloise M. Roper, Cally Dombrowski, Jamille G. de Souza, Rodrigo M. Marinho, Claudio R. F. Sutherland, Colin J. Hibberd, Martin L. Mohareb, Fady Baker, David A. Clark, Taane G. Campino, Susana Sci Rep Article Malaria infection during pregnancy, caused by the sequestering of Plasmodium falciparum parasites in the placenta, leads to high infant mortality and maternal morbidity. The parasite-placenta adherence mechanism is mediated by the VAR2CSA protein, a target for natural occurring immunity. Currently, vaccine development is based on its ID1-DBL2Xb domain however little is known about the global genetic diversity of the encoding var2csa gene, which could influence vaccine efficacy. In a comprehensive analysis of the var2csa gene in >2,000 P. falciparum field isolates across 23 countries, we found that var2csa is duplicated in high prevalence (>25%), African and Oceanian populations harbour a much higher diversity than other regions, and that insertions/deletions are abundant leading to an underestimation of the diversity of the locus. Further, ID1-DBL2Xb haplotypes associated with adverse birth outcomes are present globally, and African-specific haplotypes exist, which should be incorporated into vaccine design. Nature Publishing Group UK 2018-10-18 /pmc/articles/PMC6193930/ /pubmed/30337594 http://dx.doi.org/10.1038/s41598-018-33767-3 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Benavente, Ernest Diez Oresegun, Damilola R. de Sessions, Paola Florez Walker, Eloise M. Roper, Cally Dombrowski, Jamille G. de Souza, Rodrigo M. Marinho, Claudio R. F. Sutherland, Colin J. Hibberd, Martin L. Mohareb, Fady Baker, David A. Clark, Taane G. Campino, Susana Global genetic diversity of var2csa in Plasmodium falciparum with implications for malaria in pregnancy and vaccine development |
title | Global genetic diversity of var2csa in Plasmodium falciparum with implications for malaria in pregnancy and vaccine development |
title_full | Global genetic diversity of var2csa in Plasmodium falciparum with implications for malaria in pregnancy and vaccine development |
title_fullStr | Global genetic diversity of var2csa in Plasmodium falciparum with implications for malaria in pregnancy and vaccine development |
title_full_unstemmed | Global genetic diversity of var2csa in Plasmodium falciparum with implications for malaria in pregnancy and vaccine development |
title_short | Global genetic diversity of var2csa in Plasmodium falciparum with implications for malaria in pregnancy and vaccine development |
title_sort | global genetic diversity of var2csa in plasmodium falciparum with implications for malaria in pregnancy and vaccine development |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193930/ https://www.ncbi.nlm.nih.gov/pubmed/30337594 http://dx.doi.org/10.1038/s41598-018-33767-3 |
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