Glaulactams A–C, daphniphyllum alkaloids from Daphniphyllum glaucescens

Glaulactams A–C (1–3), which possess a novel skeleton, as well as the known compound daphmanidin B (4), were isolated from the leaves of Daphniphyllum glaucescens and separated using ion-exchange chromatography aided by NMR fingerprinting. Their structures, including their absolute configurations, w...

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Autores principales: Chao, Chih-Hua, Cheng, Ju-Chien, Gonçalves, Théo P., Huang, Kuo-Wei, Lin, Chi-Chien, Huang, Hui-Chi, Hwang, Syh-Yuan, Wu, Yang-Chang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193994/
https://www.ncbi.nlm.nih.gov/pubmed/30337630
http://dx.doi.org/10.1038/s41598-018-33748-6
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author Chao, Chih-Hua
Cheng, Ju-Chien
Gonçalves, Théo P.
Huang, Kuo-Wei
Lin, Chi-Chien
Huang, Hui-Chi
Hwang, Syh-Yuan
Wu, Yang-Chang
author_facet Chao, Chih-Hua
Cheng, Ju-Chien
Gonçalves, Théo P.
Huang, Kuo-Wei
Lin, Chi-Chien
Huang, Hui-Chi
Hwang, Syh-Yuan
Wu, Yang-Chang
author_sort Chao, Chih-Hua
collection PubMed
description Glaulactams A–C (1–3), which possess a novel skeleton, as well as the known compound daphmanidin B (4), were isolated from the leaves of Daphniphyllum glaucescens and separated using ion-exchange chromatography aided by NMR fingerprinting. Their structures, including their absolute configurations, were elucidated by spectroscopic analyses and time-dependent density-functional-theory-calculated electronic circular dichroism spectra; the data were subsequently analyzed to gain insight into the respective biogenetic relationships between the isolates, which exhibited anti-H1N1 and immunosuppressive activities.
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spelling pubmed-61939942018-10-24 Glaulactams A–C, daphniphyllum alkaloids from Daphniphyllum glaucescens Chao, Chih-Hua Cheng, Ju-Chien Gonçalves, Théo P. Huang, Kuo-Wei Lin, Chi-Chien Huang, Hui-Chi Hwang, Syh-Yuan Wu, Yang-Chang Sci Rep Article Glaulactams A–C (1–3), which possess a novel skeleton, as well as the known compound daphmanidin B (4), were isolated from the leaves of Daphniphyllum glaucescens and separated using ion-exchange chromatography aided by NMR fingerprinting. Their structures, including their absolute configurations, were elucidated by spectroscopic analyses and time-dependent density-functional-theory-calculated electronic circular dichroism spectra; the data were subsequently analyzed to gain insight into the respective biogenetic relationships between the isolates, which exhibited anti-H1N1 and immunosuppressive activities. Nature Publishing Group UK 2018-10-18 /pmc/articles/PMC6193994/ /pubmed/30337630 http://dx.doi.org/10.1038/s41598-018-33748-6 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Chao, Chih-Hua
Cheng, Ju-Chien
Gonçalves, Théo P.
Huang, Kuo-Wei
Lin, Chi-Chien
Huang, Hui-Chi
Hwang, Syh-Yuan
Wu, Yang-Chang
Glaulactams A–C, daphniphyllum alkaloids from Daphniphyllum glaucescens
title Glaulactams A–C, daphniphyllum alkaloids from Daphniphyllum glaucescens
title_full Glaulactams A–C, daphniphyllum alkaloids from Daphniphyllum glaucescens
title_fullStr Glaulactams A–C, daphniphyllum alkaloids from Daphniphyllum glaucescens
title_full_unstemmed Glaulactams A–C, daphniphyllum alkaloids from Daphniphyllum glaucescens
title_short Glaulactams A–C, daphniphyllum alkaloids from Daphniphyllum glaucescens
title_sort glaulactams a–c, daphniphyllum alkaloids from daphniphyllum glaucescens
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193994/
https://www.ncbi.nlm.nih.gov/pubmed/30337630
http://dx.doi.org/10.1038/s41598-018-33748-6
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