Production of hypoallergenic milk from DNA-free beta-lactoglobulin (BLG) gene knockout cow using zinc-finger nucleases mRNA

The whey protein β-lactoglobulin (BLG) is a major milk allergen which is absent in human milk. Here, we for the first time generated DNA-free BLG bi-allelic knockout cow by zinc-finger nuclease (ZFNs) mRNA and produced BLG-free milk. According to the allergenicity evaluation of BLG-free milk, we fou...

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Detalles Bibliográficos
Autores principales: Sun, Zhaolin, Wang, Ming, Han, Shiwen, Ma, Shuangyu, Zou, Zhiyuan, Ding, Fangrong, Li, Xinrui, Li, Ling, Tang, Bo, Wang, Haiping, Li, Ning, Che, Huilian, Dai, Yunping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194018/
https://www.ncbi.nlm.nih.gov/pubmed/30337546
http://dx.doi.org/10.1038/s41598-018-32024-x

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