An autoimmune disease risk SNP, rs2281808, in SIRPG is associated with reduced expression of SIRPγ and heightened effector state in human CD8 T-cells

Multiple GWAS studies have shown that the SNP rs2281808 TT variant, present within the SIRPG gene, is associated with autoimmune diseases, such as type 1 diabetes. However, the role of SIRPγ in human T-cells is not known, neither is the functional significance of TT variant. Here we investigated SIR...

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Detalles Bibliográficos
Autores principales: Sinha, Sushmita, Borcherding, Nicholas, Renavikar, Pranav S., Crawford, Michael P., Tsalikian, Eva, Tansey, Michael, Shivapour, Ezzatollah T., Bittner, Frank, Kamholz, John, Olalde, Heena, Gibson, Emilee, Karandikar, Nitin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194019/
https://www.ncbi.nlm.nih.gov/pubmed/30337675
http://dx.doi.org/10.1038/s41598-018-33901-1

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