Cryo-EM structures of human STEAP4 reveal mechanism of iron(III) reduction

Enzymes of the six-transmembrane epithelial antigen of the prostate (STEAP) family reduce Fe(3+) and Cu(2+) ions to facilitate metal-ion uptake by mammalian cells. STEAPs are highly upregulated in several types of cancer, making them potential therapeutic targets. However, the structural basis for S...

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Detalles Bibliográficos
Autores principales: Oosterheert, Wout, van Bezouwen, Laura S., Rodenburg, Remco N. P., Granneman, Joke, Förster, Friedrich, Mattevi, Andrea, Gros, Piet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194020/
https://www.ncbi.nlm.nih.gov/pubmed/30337524
http://dx.doi.org/10.1038/s41467-018-06817-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194020/
https://www.ncbi.nlm.nih.gov/pubmed/30337524
http://dx.doi.org/10.1038/s41467-018-06817-7

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