Genetic enhancement of Ras-ERK pathway does not aggravate L-DOPA-induced dyskinesia in mice but prevents the decrease induced by lovastatin

Increasing evidence supports a close relationship between Ras-ERK1/2 activation in the striatum and L-DOPA-induced dyskinesia (LID). ERK1/2 activation by L-DOPA takes place through the crosstalk between D1R/AC/PKA/DARPP-32 pathway and NMDA/Ras pathway. Compelling genetic and pharmacological evidence...

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Detalles Bibliográficos
Autores principales: Ruiz-DeDiego, Irene, Fasano, Stefania, Solís, Oscar, Garcia-Montes, José-Rubén, Brea, José, Loza, María I., Brambilla, Riccardo, Moratalla, Rosario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194127/
https://www.ncbi.nlm.nih.gov/pubmed/30337665
http://dx.doi.org/10.1038/s41598-018-33713-3

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