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Metabolic Characterization of Antifolate Responsiveness and Non-responsiveness in Malignant Pleural Mesothelioma Cells

Antifolates are a class of drugs effective for treating malignant pleural mesothelioma (MPM). The majority of antifolates inhibit enzymes involved in purine and pyrimidine synthesis such as dihydrofolate reductase (DHFR), thymidylate synthase (TYMS), and glycinamide ribonucleotide formyltransferase...

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Detalles Bibliográficos
Autores principales:	Sato, Yuzo, Matsuda, Shiori, Maruyama, Ami, Nakayama, Joji, Miyashita, Tomoyuki, Udagawa, Hibiki, Umemura, Shigeki, Yanagihara, Kazuyoshi, Ochiai, Atsushi, Tomita, Masaru, Soga, Tomoyoshi, Tsuchihara, Katsuya, Makinoshima, Hideki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194193/ https://www.ncbi.nlm.nih.gov/pubmed/30369878 http://dx.doi.org/10.3389/fphar.2018.01129

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