Cargando…

Simulated Microgravity Altered the Metabolism of Loureirin B and the Expression of Major Cytochrome P450 in Liver of Rats

Loureirin B (LB) is the marker compound of dragon blood (DB), which exhibits great potentials in protecting astronauts’ health against radiation and simulated microgravity (SM). Pharmacokinetics of LB is reported to be significantly altered by SM. Here, we investigated key metabolic features of LB i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Bo, Guo, Jingjing, Wang, Shibo, Kang, Liting, Deng, Yulin, Li, Yujuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194197/ https://www.ncbi.nlm.nih.gov/pubmed/30369879 http://dx.doi.org/10.3389/fphar.2018.01130

Ejemplares similares

Gut Microbiome Alters the Activity of Liver Cytochromes P450 in Mice With Sex-Dependent Differences
por: Jourová, Lenka, et al.
Publicado: (2020)

Alterations of Cytochrome P450s and UDP-Glucuronosyltransferases in Brain Under Diseases and Their Clinical Significances
por: Sheng, Yun, et al.
Publicado: (2021)

The Role of Cytochrome P450 Enzymes in COVID-19 Pathogenesis and Therapy
por: Wang, Guyi, et al.
Publicado: (2022)

Characterization of the metabolism of eupalinolide A and B by carboxylesterase and cytochrome P450 in human liver microsomes
por: Li, Yingzi, et al.
Publicado: (2023)

Loureirin B Exerts its Immunosuppressive Effects by Inhibiting STIM1/Orai1 and K(V)1.3 Channels
por: Shi, Shujuan, et al.
Publicado: (2021)

Simulated Microgravity Alters P-Glycoprotein Efflux Function and Expression via the Wnt/β-Catenin Signaling Pathway in Rat Intestine and Brain
por: Liu, Huayan, et al.
Publicado: (2023)

Investigation on Intestinal Proteins and Drug Metabolizing Enzymes in Simulated Microgravity Rats by a Proteomics Method
por: Liu, Huayan, et al.
Publicado: (2020)

Modeling of interactions between xenobiotics and cytochrome P450 (CYP) enzymes
por: Raunio, Hannu, et al.
Publicado: (2015)

Pleiotropic Functions of Cytochrome P450 Monooxygenase-Derived Eicosanoids in Cancer
por: Luo, Ying, et al.
Publicado: (2020)

Inflammatory signaling on cytochrome P450-mediated drug metabolism in hepatocytes
por: Wang, Xiaokang, et al.
Publicado: (2022)

Inhibitory effect of Selaginella doederleinii hieron on human cytochrome P450
por: Lin, Fei, et al.
Publicado: (2023)

Expression and Function of Eicosanoid-Producing Cytochrome P450 Enzymes in Solid Tumors
por: Evangelista, Eric A., et al.
Publicado: (2020)

Cytochrome P450-Based Drug-Drug Interactions of Vonoprazan In Vitro and In Vivo
por: Wang, Yiran, et al.
Publicado: (2020)

Effects of Cytochrome P450 and Transporter Polymorphisms on the Bioavailability and Safety of Dutasteride and Tamsulosin
por: Villapalos-García, Gonzalo, et al.
Publicado: (2021)

Sorafenib increases cytochrome P450 lipid metabolites in patient with hepatocellular carcinoma
por: Leineweber, Can G., et al.
Publicado: (2023)

Functioning of Microsomal Cytochrome P450s: Murburn Concept Explains the Metabolism of Xenobiotics in Hepatocytes
por: Manoj, Kelath Murali, et al.
Publicado: (2016)

The Functions of Cytochrome P450 ω-hydroxylases and the Associated Eicosanoids in Inflammation-Related Diseases
por: Ni, Kai-Di, et al.
Publicado: (2021)

Interactive Effects of Glucocorticoids and Cytochrome P450 Polymorphisms on the Plasma Trough Concentrations of Voriconazole
por: Jia, Su-jie, et al.
Publicado: (2021)

Influence of Inflammation on Cytochromes P450 Activity in Adults: A Systematic Review of the Literature
por: Lenoir, Camille, et al.
Publicado: (2021)

DEEPCYPs: A deep learning platform for enhanced cytochrome P450 activity prediction
por: Ai, Daiqiao, et al.
Publicado: (2023)

Human induced pluripotent stem cell–derived liver-on-a-chip for studying drug metabolism: the challenge of the cytochrome P450 family
por: Tamargo-Rubio, Isabel, et al.
Publicado: (2023)

Inhibitory mechanism of vortioxetine on CYP450 enzymes in human and rat liver microsomes
por: Zhan, Yunyun, et al.
Publicado: (2023)

Cytochrome P450 1A2 Is Incapable of Oxidizing Bilirubin Under Physiological Conditions
por: Li, Xinyi, et al.
Publicado: (2019)

SNPs in cytochrome P450 genes decide on the fate of individuals with genetic predisposition to Parkinson’s disease
por: Petkova-Kirova, Polina, et al.
Publicado: (2023)

Cytochrome P450 3A Enzymes Are Key Contributors for Hepatic Metabolism of Bufotalin, a Natural Constitute in Chinese Medicine Chansu
por: Dai, Zi-Ru, et al.
Publicado: (2019)

Introduction of an N-Glycosylation Site into UDP-Glucuronosyltransferase 2B3 Alters Its Sensitivity to Cytochrome P450 3A1-Dependent Modulation
por: Nakamura, Tatsuro, et al.
Publicado: (2016)

Computational Insight Into Vitamin K(1) ω-Hydroxylation by Cytochrome P450 4F2
por: Li, Junhao, et al.
Publicado: (2018)

Membrane Associated Progesterone Receptors: Promiscuous Proteins with Pleiotropic Functions – Focus on Interactions with Cytochromes P450
por: Ryu, Chang S., et al.
Publicado: (2017)

Inhibition and Induction by Poziotinib of Different Rat Cytochrome P450 Enzymes In Vivo and in an In Vitro Cocktail Method
por: Wang, Jinhui, et al.
Publicado: (2021)

Effects of Diminished NADPH:cytochrome P450 Reductase in Human Hepatocytes on Lipid and Bile Acid Homeostasis
por: Heintze, Tamara, et al.
Publicado: (2021)

Cocaine-Induced Time-Dependent Alterations in Cytochrome P450 and Liver Function
por: Jastrzębska, Joanna, et al.
Publicado: (2023)

Simultaneous absolute protein quantification of seven cytochrome P450 isoforms in rat liver microsomes by LC-MS/MS-based isotope internal standard method
por: Jiang, Fulin, et al.
Publicado: (2022)

Potent Inhibition of Human Cytochrome P450 3A4 by Biflavone Components from Ginkgo Biloba and Selaginella Tamariscina
por: Wang, Bo, et al.
Publicado: (2022)

The Hinge Segment of Human NADPH-Cytochrome P450 Reductase in Conformational Switching: The Critical Role of Ionic Strength
por: Campelo, Diana, et al.
Publicado: (2017)

Effects of dapagliflozin in combination with insulin on cytochrome P450 activities in a diabetes type 1 rat model
por: SAYED, Noha, et al.
Publicado: (2021)

Hepatic Cytochrome P450 Abundance and Activity in the Developing and Adult Göttingen Minipig: Pivotal Data for PBPK Modeling
por: Buyssens, Laura, et al.
Publicado: (2021)

Regulation of Cytochrome P450 2a5 by Artemisia capillaris and 6,7-Dimethylesculetin in Mouse Hepatocytes
por: Kim, Sangsoo Daniel, et al.
Publicado: (2021)

Correlation of Cytochrome P450 Oxidoreductase Expression with the Expression of 10 Isoforms of Cytochrome P450 in Human Liver
por: Zhang, Hai-Feng, et al.
Publicado: (2016)

Correction: The Hinge Segment of Human NADPH-Cytochrome P450 Reductase in Conformational Switching: The Critical Role of Ionic Strength
por: Campelo, Diana, et al.
Publicado: (2018)

The Ontogeny of Cytochrome P450 Enzyme Activity and Protein Abundance in Conventional Pigs in Support of Preclinical Pediatric Drug Research
por: Millecam, Joske, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_3ncu1lonf1aquivft13m1nv5gp