Synapse Type-Dependent Expression of Calcium-Permeable AMPA Receptors

Calcium-permeable (CP) AMPA-type glutamate receptors (AMPARs) are known to mediate synaptic plasticity in several different interneuron (IN) types. Recent evidence suggests that CP-AMPARs are synapse-specifically expressed at excitatory connections onto a subset of IN types in hippocampus and neocor...

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Autores principales: Lalanne, Txomin, Oyrer, Julia, Farrant, Mark, Sjöström, P. Jesper
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Synaptic Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194349/
https://www.ncbi.nlm.nih.gov/pubmed/30369875
http://dx.doi.org/10.3389/fnsyn.2018.00034
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author Lalanne, Txomin
Oyrer, Julia
Farrant, Mark
Sjöström, P. Jesper
author_facet Lalanne, Txomin
Oyrer, Julia
Farrant, Mark
Sjöström, P. Jesper
author_sort Lalanne, Txomin
collection PubMed
description Calcium-permeable (CP) AMPA-type glutamate receptors (AMPARs) are known to mediate synaptic plasticity in several different interneuron (IN) types. Recent evidence suggests that CP-AMPARs are synapse-specifically expressed at excitatory connections onto a subset of IN types in hippocampus and neocortex. For example, CP-AMPARs are found at connections from pyramidal cells (PCs) to basket cells (BCs), but not to Martinotti cells (MCs). This synapse type-specific expression of CP-AMPARs suggests that synaptic dynamics as well as learning rules are differentially implemented in local circuits and has important implications not just in health but also in disease states such as epilepsy.
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spelling pubmed-61943492018-10-26 Synapse Type-Dependent Expression of Calcium-Permeable AMPA Receptors Lalanne, Txomin Oyrer, Julia Farrant, Mark Sjöström, P. Jesper Front Synaptic Neurosci Synaptic Neuroscience Calcium-permeable (CP) AMPA-type glutamate receptors (AMPARs) are known to mediate synaptic plasticity in several different interneuron (IN) types. Recent evidence suggests that CP-AMPARs are synapse-specifically expressed at excitatory connections onto a subset of IN types in hippocampus and neocortex. For example, CP-AMPARs are found at connections from pyramidal cells (PCs) to basket cells (BCs), but not to Martinotti cells (MCs). This synapse type-specific expression of CP-AMPARs suggests that synaptic dynamics as well as learning rules are differentially implemented in local circuits and has important implications not just in health but also in disease states such as epilepsy. Frontiers Media S.A. 2018-10-12 /pmc/articles/PMC6194349/ /pubmed/30369875 http://dx.doi.org/10.3389/fnsyn.2018.00034 Text en Copyright © 2018 Lalanne, Oyrer, Farrant and Sjöström. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Synaptic Neuroscience
Lalanne, Txomin
Oyrer, Julia
Farrant, Mark
Sjöström, P. Jesper
Synapse Type-Dependent Expression of Calcium-Permeable AMPA Receptors
title Synapse Type-Dependent Expression of Calcium-Permeable AMPA Receptors
title_full Synapse Type-Dependent Expression of Calcium-Permeable AMPA Receptors
title_fullStr Synapse Type-Dependent Expression of Calcium-Permeable AMPA Receptors
title_full_unstemmed Synapse Type-Dependent Expression of Calcium-Permeable AMPA Receptors
title_short Synapse Type-Dependent Expression of Calcium-Permeable AMPA Receptors
title_sort synapse type-dependent expression of calcium-permeable ampa receptors
topic Synaptic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194349/
https://www.ncbi.nlm.nih.gov/pubmed/30369875
http://dx.doi.org/10.3389/fnsyn.2018.00034
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