Targeted integration in human cells through single crossover mediated by ZFN or CRISPR/Cas9

BACKGROUND: Targeted DNA integration is widely used in basic research and commercial applications because it eliminates positional effects on transgene expression. Targeted integration in mammalian cells is generally achieved through a double crossover event between the genome and a linear donor con...

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Detalles Bibliográficos
Autores principales: Liu, Xiaofeng, Wang, Min, Qin, Yufeng, Shi, Xuan, Cong, Peiqing, Chen, Yaosheng, He, Zuyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194632/
https://www.ncbi.nlm.nih.gov/pubmed/30340581
http://dx.doi.org/10.1186/s12896-018-0474-6

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