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Inflammation marker ESR is effective in predicting outcome of diffuse large B-cell lymphoma

BACKGROUND: Systemic inflammation has been implicated in cancer development and progression. This study examined the best cutoff value of erythrocyte sedimentation rate (ESR) in diffuse large B-cell lymphoma (DLBCL) patients. METHODS: The relationship between ESR and clinical characteristics was ana...

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Autores principales: Wu, Shuang, Zhou, Ye, Hua, Hai-Ying, Zhang, Yan, Zhu, Wen-Yan, Wang, Zhi-Qing, Li, Jin, Gao, Hua-Qiang, Wu, Xiao-Hong, Lu, Ting-Xun, Hua, Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194702/
https://www.ncbi.nlm.nih.gov/pubmed/30340560
http://dx.doi.org/10.1186/s12885-018-4914-4
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author Wu, Shuang
Zhou, Ye
Hua, Hai-Ying
Zhang, Yan
Zhu, Wen-Yan
Wang, Zhi-Qing
Li, Jin
Gao, Hua-Qiang
Wu, Xiao-Hong
Lu, Ting-Xun
Hua, Dong
author_facet Wu, Shuang
Zhou, Ye
Hua, Hai-Ying
Zhang, Yan
Zhu, Wen-Yan
Wang, Zhi-Qing
Li, Jin
Gao, Hua-Qiang
Wu, Xiao-Hong
Lu, Ting-Xun
Hua, Dong
author_sort Wu, Shuang
collection PubMed
description BACKGROUND: Systemic inflammation has been implicated in cancer development and progression. This study examined the best cutoff value of erythrocyte sedimentation rate (ESR) in diffuse large B-cell lymphoma (DLBCL) patients. METHODS: The relationship between ESR and clinical characteristics was analyzed in 182 DLBCL patients from 2006 to 2017. The log-rank test, univariate analysis, and Cox regression analysis were applied to evaluate the relationship between ESR and survival. An ESR of more than 37.5 mm/hour was found to be the optimal threshold value for predicting prognosis. RESULTS: ESR was associated with more frequent advanced Ann Arbor stage, poorer performance status, elevated lactate dehydrogenase level, the presence of B symptoms, high-risk International Prognostic Index (IPI 3–5), more extranodal involvement (ENI ≥2), non-germinal-center B-cell (non-GCB) subtypes, and more frequent Myc protein positivity. Shorter overall survival (OS) and progression-free survival (PFS) were found for patients with higher ESRs. Multivariate analysis demonstrated that ESR level is an independent prognostic factor of both OS and PFS. In addition, dynamic changes in ESR are valuable in assessing curative effect and predicting disease recurrence. CONCLUSION: High ESR in DLBCL patients indicated unfavorable prognosis that may require alternative treatment regimens. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12885-018-4914-4) contains supplementary material, which is available to authorized users.
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spelling pubmed-61947022018-10-30 Inflammation marker ESR is effective in predicting outcome of diffuse large B-cell lymphoma Wu, Shuang Zhou, Ye Hua, Hai-Ying Zhang, Yan Zhu, Wen-Yan Wang, Zhi-Qing Li, Jin Gao, Hua-Qiang Wu, Xiao-Hong Lu, Ting-Xun Hua, Dong BMC Cancer Research Article BACKGROUND: Systemic inflammation has been implicated in cancer development and progression. This study examined the best cutoff value of erythrocyte sedimentation rate (ESR) in diffuse large B-cell lymphoma (DLBCL) patients. METHODS: The relationship between ESR and clinical characteristics was analyzed in 182 DLBCL patients from 2006 to 2017. The log-rank test, univariate analysis, and Cox regression analysis were applied to evaluate the relationship between ESR and survival. An ESR of more than 37.5 mm/hour was found to be the optimal threshold value for predicting prognosis. RESULTS: ESR was associated with more frequent advanced Ann Arbor stage, poorer performance status, elevated lactate dehydrogenase level, the presence of B symptoms, high-risk International Prognostic Index (IPI 3–5), more extranodal involvement (ENI ≥2), non-germinal-center B-cell (non-GCB) subtypes, and more frequent Myc protein positivity. Shorter overall survival (OS) and progression-free survival (PFS) were found for patients with higher ESRs. Multivariate analysis demonstrated that ESR level is an independent prognostic factor of both OS and PFS. In addition, dynamic changes in ESR are valuable in assessing curative effect and predicting disease recurrence. CONCLUSION: High ESR in DLBCL patients indicated unfavorable prognosis that may require alternative treatment regimens. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12885-018-4914-4) contains supplementary material, which is available to authorized users. BioMed Central 2018-10-19 /pmc/articles/PMC6194702/ /pubmed/30340560 http://dx.doi.org/10.1186/s12885-018-4914-4 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Wu, Shuang
Zhou, Ye
Hua, Hai-Ying
Zhang, Yan
Zhu, Wen-Yan
Wang, Zhi-Qing
Li, Jin
Gao, Hua-Qiang
Wu, Xiao-Hong
Lu, Ting-Xun
Hua, Dong
Inflammation marker ESR is effective in predicting outcome of diffuse large B-cell lymphoma
title Inflammation marker ESR is effective in predicting outcome of diffuse large B-cell lymphoma
title_full Inflammation marker ESR is effective in predicting outcome of diffuse large B-cell lymphoma
title_fullStr Inflammation marker ESR is effective in predicting outcome of diffuse large B-cell lymphoma
title_full_unstemmed Inflammation marker ESR is effective in predicting outcome of diffuse large B-cell lymphoma
title_short Inflammation marker ESR is effective in predicting outcome of diffuse large B-cell lymphoma
title_sort inflammation marker esr is effective in predicting outcome of diffuse large b-cell lymphoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194702/
https://www.ncbi.nlm.nih.gov/pubmed/30340560
http://dx.doi.org/10.1186/s12885-018-4914-4
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