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A modified M-stage classification based on the metastatic patterns of pancreatic neuroendocrine neoplasms: a population-based study

BACKGROUND: The present study aims to improve the M-stage classification of pancreatic neuroendocrine neoplasms (pNENs). METHODS: Two thousand six hundred sixty six pNENs were extracted from the Surveillance, Epidemiology, and End Results database to explore the metastatic patterns of pNENs. Metasta...

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Autores principales: Zhang, Xianbin, Song, Jiaxin, Liu, Peng, Mazid, Mohammad Abdul, Lu, Lili, Shang, Yuru, Wei, Yushan, Gong, Peng, Ma, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194708/
https://www.ncbi.nlm.nih.gov/pubmed/30340569
http://dx.doi.org/10.1186/s12902-018-0301-z
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author Zhang, Xianbin
Song, Jiaxin
Liu, Peng
Mazid, Mohammad Abdul
Lu, Lili
Shang, Yuru
Wei, Yushan
Gong, Peng
Ma, Li
author_facet Zhang, Xianbin
Song, Jiaxin
Liu, Peng
Mazid, Mohammad Abdul
Lu, Lili
Shang, Yuru
Wei, Yushan
Gong, Peng
Ma, Li
author_sort Zhang, Xianbin
collection PubMed
description BACKGROUND: The present study aims to improve the M-stage classification of pancreatic neuroendocrine neoplasms (pNENs). METHODS: Two thousand six hundred sixty six pNENs were extracted from the Surveillance, Epidemiology, and End Results database to explore the metastatic patterns of pNENs. Metastatic patterns were categorized as single, two, or multiple (three or more) distant organ metastasis. The mean overall survival and hazard rate of different metastatic patterns were calculated by Kaplan-Meier and Cox proportional hazards models, respectively. The discriminatory capability of the modified M-stage classification was evaluated by Harrell’s concordance index. RESULTS: The overall survival time significantly decreased with an increasing number of metastatic organs. In addition, pNENs with only liver metastasis had better prognosis when compared to other metastatic patterns. Thus, we modified the M-stage classification (mM-stage) as follows: mM(0)-stage, tumor without metastasis; mM(1)-stage, tumor only metastasized to liver; mM(2)-stage, tumor metastasized to other single distant organ (lung, bone, or brain) or two distant organs; mM(3)-stage, tumor metastasized to three or more distant organs. Harrell’s concordance index showed that the modified M-stage classification had superior discriminatory capability than both the American Joint Committee on Cancer (AJCC) and the European Neuroendocrine Tumor Society (ENETS) M-stage classifications. CONCLUSIONS: The modified M-stage classification is superior to both AJCC and ENETS M-stage classifications in the prognosis of pNENs. In the future, individualized treatment and follow-up programs should be explored for patients with distinct metastatic patterns. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12902-018-0301-z) contains supplementary material, which is available to authorized users.
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spelling pubmed-61947082018-10-30 A modified M-stage classification based on the metastatic patterns of pancreatic neuroendocrine neoplasms: a population-based study Zhang, Xianbin Song, Jiaxin Liu, Peng Mazid, Mohammad Abdul Lu, Lili Shang, Yuru Wei, Yushan Gong, Peng Ma, Li BMC Endocr Disord Research Article BACKGROUND: The present study aims to improve the M-stage classification of pancreatic neuroendocrine neoplasms (pNENs). METHODS: Two thousand six hundred sixty six pNENs were extracted from the Surveillance, Epidemiology, and End Results database to explore the metastatic patterns of pNENs. Metastatic patterns were categorized as single, two, or multiple (three or more) distant organ metastasis. The mean overall survival and hazard rate of different metastatic patterns were calculated by Kaplan-Meier and Cox proportional hazards models, respectively. The discriminatory capability of the modified M-stage classification was evaluated by Harrell’s concordance index. RESULTS: The overall survival time significantly decreased with an increasing number of metastatic organs. In addition, pNENs with only liver metastasis had better prognosis when compared to other metastatic patterns. Thus, we modified the M-stage classification (mM-stage) as follows: mM(0)-stage, tumor without metastasis; mM(1)-stage, tumor only metastasized to liver; mM(2)-stage, tumor metastasized to other single distant organ (lung, bone, or brain) or two distant organs; mM(3)-stage, tumor metastasized to three or more distant organs. Harrell’s concordance index showed that the modified M-stage classification had superior discriminatory capability than both the American Joint Committee on Cancer (AJCC) and the European Neuroendocrine Tumor Society (ENETS) M-stage classifications. CONCLUSIONS: The modified M-stage classification is superior to both AJCC and ENETS M-stage classifications in the prognosis of pNENs. In the future, individualized treatment and follow-up programs should be explored for patients with distinct metastatic patterns. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12902-018-0301-z) contains supplementary material, which is available to authorized users. BioMed Central 2018-10-19 /pmc/articles/PMC6194708/ /pubmed/30340569 http://dx.doi.org/10.1186/s12902-018-0301-z Text en © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Zhang, Xianbin
Song, Jiaxin
Liu, Peng
Mazid, Mohammad Abdul
Lu, Lili
Shang, Yuru
Wei, Yushan
Gong, Peng
Ma, Li
A modified M-stage classification based on the metastatic patterns of pancreatic neuroendocrine neoplasms: a population-based study
title A modified M-stage classification based on the metastatic patterns of pancreatic neuroendocrine neoplasms: a population-based study
title_full A modified M-stage classification based on the metastatic patterns of pancreatic neuroendocrine neoplasms: a population-based study
title_fullStr A modified M-stage classification based on the metastatic patterns of pancreatic neuroendocrine neoplasms: a population-based study
title_full_unstemmed A modified M-stage classification based on the metastatic patterns of pancreatic neuroendocrine neoplasms: a population-based study
title_short A modified M-stage classification based on the metastatic patterns of pancreatic neuroendocrine neoplasms: a population-based study
title_sort modified m-stage classification based on the metastatic patterns of pancreatic neuroendocrine neoplasms: a population-based study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194708/
https://www.ncbi.nlm.nih.gov/pubmed/30340569
http://dx.doi.org/10.1186/s12902-018-0301-z
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