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HIF-2α promotes conversion to a stem cell phenotype and induces chemoresistance in breast cancer cells by activating Wnt and Notch pathways

BACKGROUND: Hypoxic tumor microenvironment and maintenance of stemness contribute to drug resistance in breast cancer. However, whether Hypoxia-inducible factor-2α (HIF-2α) in hypoxic tumor microenvironment mediates conversion to a stem cell phenotype and chemoresistance of breast tumors has not bee...

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Detalles Bibliográficos
Autores principales:	Yan, Yuanyuan, Liu, Fangxiao, Han, Li, Zhao, Lin, Chen, Jianjun, Olopade, Olufunmilayo I, He, Miao, Wei, Minjie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194720/ https://www.ncbi.nlm.nih.gov/pubmed/30340507 http://dx.doi.org/10.1186/s13046-018-0925-x

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