Troubleshooting for F-18 Fluorocholine Synthesis: An Institutional Experience

Choline is a natural substrate for phospholipid synthesis. F-18 labeled fluorocholine nowadays is routinely used for imaging brain tumors, parathyroid adenoma, and prostate cancer. It is synthesized through nucleophilic substitution reaction using dibromomethane and N, N-dimethylaminoethanol as prim...

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Autores principales: Vatsa, Rakhee, Joshi, Raman Kumar, Shukla, Jaya, Mittal, Bhagwant Rai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2018
Materias:
Technical Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194756/
https://www.ncbi.nlm.nih.gov/pubmed/30386063
http://dx.doi.org/10.4103/ijnm.IJNM_85_18
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author Vatsa, Rakhee
Joshi, Raman Kumar
Shukla, Jaya
Mittal, Bhagwant Rai
author_facet Vatsa, Rakhee
Joshi, Raman Kumar
Shukla, Jaya
Mittal, Bhagwant Rai
author_sort Vatsa, Rakhee
collection PubMed
description Choline is a natural substrate for phospholipid synthesis. F-18 labeled fluorocholine nowadays is routinely used for imaging brain tumors, parathyroid adenoma, and prostate cancer. It is synthesized through nucleophilic substitution reaction using dibromomethane and N, N-dimethylaminoethanol as primary and secondary precursors, respectively. However, sometimes, failures are encountered in F-18 fluorocholine production. Few problems and troubleshooting during synthesis are discussed here.
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spelling pubmed-61947562018-10-31 Troubleshooting for F-18 Fluorocholine Synthesis: An Institutional Experience Vatsa, Rakhee Joshi, Raman Kumar Shukla, Jaya Mittal, Bhagwant Rai Indian J Nucl Med Technical Note Choline is a natural substrate for phospholipid synthesis. F-18 labeled fluorocholine nowadays is routinely used for imaging brain tumors, parathyroid adenoma, and prostate cancer. It is synthesized through nucleophilic substitution reaction using dibromomethane and N, N-dimethylaminoethanol as primary and secondary precursors, respectively. However, sometimes, failures are encountered in F-18 fluorocholine production. Few problems and troubleshooting during synthesis are discussed here. Medknow Publications & Media Pvt Ltd 2018 /pmc/articles/PMC6194756/ /pubmed/30386063 http://dx.doi.org/10.4103/ijnm.IJNM_85_18 Text en Copyright: © 2018 Indian Journal of Nuclear Medicine http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Technical Note
Vatsa, Rakhee
Joshi, Raman Kumar
Shukla, Jaya
Mittal, Bhagwant Rai
Troubleshooting for F-18 Fluorocholine Synthesis: An Institutional Experience
title Troubleshooting for F-18 Fluorocholine Synthesis: An Institutional Experience
title_full Troubleshooting for F-18 Fluorocholine Synthesis: An Institutional Experience
title_fullStr Troubleshooting for F-18 Fluorocholine Synthesis: An Institutional Experience
title_full_unstemmed Troubleshooting for F-18 Fluorocholine Synthesis: An Institutional Experience
title_short Troubleshooting for F-18 Fluorocholine Synthesis: An Institutional Experience
title_sort troubleshooting for f-18 fluorocholine synthesis: an institutional experience
topic Technical Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194756/
https://www.ncbi.nlm.nih.gov/pubmed/30386063
http://dx.doi.org/10.4103/ijnm.IJNM_85_18
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AT mittalbhagwantrai troubleshootingforf18fluorocholinesynthesisaninstitutionalexperience

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