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Overcoming the Cost of Positive Autoregulation by Accelerating the Response with a Coupled Negative Feedback
A fundamental trade-off between rapid response and optimal expression of genes below cytotoxic levels exists for many signaling circuits, particularly for positively autoregulated systems with an inherent response delay. Here, we describe a regulatory scheme in the E. coli PhoB-PhoR two-component sy...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194859/ https://www.ncbi.nlm.nih.gov/pubmed/30208328 http://dx.doi.org/10.1016/j.celrep.2018.08.023 |