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Obstetric antiphospholipid syndrome

The present clinical and laboratory classification criteria for antiphospholipid syndrome (APS) were established in Sydney, Australia, in 2006. In this review, we focus on the obstetric subset of APS (OAPS), defined by persistent positivity for antiphospholipid antibodies together with either early...

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Autores principales: Antovic, Aleksandra, Sennström, Maria, Bremme, Katarina, Svenungsson, Elisabet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195166/
https://www.ncbi.nlm.nih.gov/pubmed/30364418
http://dx.doi.org/10.1136/lupus-2016-000197
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author Antovic, Aleksandra
Sennström, Maria
Bremme, Katarina
Svenungsson, Elisabet
author_facet Antovic, Aleksandra
Sennström, Maria
Bremme, Katarina
Svenungsson, Elisabet
author_sort Antovic, Aleksandra
collection PubMed
description The present clinical and laboratory classification criteria for antiphospholipid syndrome (APS) were established in Sydney, Australia, in 2006. In this review, we focus on the obstetric subset of APS (OAPS), defined by persistent positivity for antiphospholipid antibodies together with either early recurrent pregnancy loss, early fetal death, stillbirth or premature birth <34 gestational weeks due to pre-eclampsia, eclampsia and placental insufficiency. It is important to diagnose these cases since most women suffering from OAPS can, when given appropriate treatment, have successful pregnancies. Furthermore, patients with OAPS may, depending on the antibody profile, be at enhanced risk of thrombotic events later in life. We present an update on the present knowledge of possible underlying pathogenesis, risk factors and risk estimations for adverse pregnancy outcomes before and during pregnancy, current treatment concepts, and long-term outcomes for women with OAPS and their children.
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spelling pubmed-61951662018-10-24 Obstetric antiphospholipid syndrome Antovic, Aleksandra Sennström, Maria Bremme, Katarina Svenungsson, Elisabet Lupus Sci Med Review The present clinical and laboratory classification criteria for antiphospholipid syndrome (APS) were established in Sydney, Australia, in 2006. In this review, we focus on the obstetric subset of APS (OAPS), defined by persistent positivity for antiphospholipid antibodies together with either early recurrent pregnancy loss, early fetal death, stillbirth or premature birth <34 gestational weeks due to pre-eclampsia, eclampsia and placental insufficiency. It is important to diagnose these cases since most women suffering from OAPS can, when given appropriate treatment, have successful pregnancies. Furthermore, patients with OAPS may, depending on the antibody profile, be at enhanced risk of thrombotic events later in life. We present an update on the present knowledge of possible underlying pathogenesis, risk factors and risk estimations for adverse pregnancy outcomes before and during pregnancy, current treatment concepts, and long-term outcomes for women with OAPS and their children. BMJ Publishing Group 2018-09-25 /pmc/articles/PMC6195166/ /pubmed/30364418 http://dx.doi.org/10.1136/lupus-2016-000197 Text en © Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Review
Antovic, Aleksandra
Sennström, Maria
Bremme, Katarina
Svenungsson, Elisabet
Obstetric antiphospholipid syndrome
title Obstetric antiphospholipid syndrome
title_full Obstetric antiphospholipid syndrome
title_fullStr Obstetric antiphospholipid syndrome
title_full_unstemmed Obstetric antiphospholipid syndrome
title_short Obstetric antiphospholipid syndrome
title_sort obstetric antiphospholipid syndrome
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195166/
https://www.ncbi.nlm.nih.gov/pubmed/30364418
http://dx.doi.org/10.1136/lupus-2016-000197
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